Scientific Papers

2015

Takeuchi S, Baghdadi M, Tsuchikawa T, Wada H, Nakamura T, Abe H, Nakanishi S, Usui Y, Higuchi K, Takahashi M, Inoko K, Sato S, Shichinohe T, Takano H, Hirano S, Seino KI.
Chemotherapy-derived inflammatory responses accelerate the formation of immunosuppressive myeloid cells in the tissue microenvironment of human pancreatic cancer.
Cancer Res. 2015 May 7. pii: canres.2921.2014.
Immunobiology

Muto M, Baghdadi M, Maekawa R, Wada H, Seino KI.
Myeloid molecular characteristics of human γδ T cells support their acquisition of tumor antigen-presenting capacity.
Cancer Immunol Immunother. 2015 Apr 24.
Immunobiology

Nishio K, Miyagi T, Tatsumi T, Mukai K, Yokoyama Y, Yoshioka T, Sakamori R, Hikita H, Kodama T, Shimizu S, Shigekawa M, Nawa T, Yoshihara H, Hiramatsu N, Yamanaka H, Seino KI, Takehara T.
Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on γδT cells in mice.
J Gastroenterol. 2015 Mar 21.
(Immunobiology)

Tetsuya Kawaguchi, Akie Tanigawa, Takao Naganuma, Yasuyuki Ohkawa, Sylvie Souquere, Gerard Pierron, and Tetsuro Hirose
SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies.
Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4304-9.
RNA Biofunction

Shingo Miyawaki, Yoshimi Kawamura, Tsuyoshi Hachiya, Atsushi Shimizu, Kyoko Miura
Molecular cloning and characterization of the INK4a and ARF genes in naked mole-rat.
Inflammation and Regeneration. 2015 35(1) pp42-50
(Biomedical Animal Research Laboratory)

Seino K, Wada H, Baghdadi M.
New immunosuppressive strategies for transplantation based on pluripotent stem cell (PSC)-derived immunoregulatory cells.
Stem Cell Transl Invest 2015; 2: e504.
(Immunobiology)

Seiichi Sato, Kai Li, Takeshi Kameyama, Takaya Hayashi, Yuji Ishida, Shuko Murakami, Tsunamasa Watanabe, Sayuki Iijima, Yu Sakurai, Koichi Watashi, Susumu Tsutsumi, Yusuke Sato, Hidetaka Akita, Takaji Wakita, Charles M. Rice, Hideyoshi Harashima, Michinori Kohara, Yasuhito Tanaka, and Akinori Takaoka
The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus
Immunity. 2015 Jan 20;42(1):123-32.
Summary (PDF)
(Signaling in Cancer and Immunology)

2014

Akiyama K, Maishi N, Ohga N, Hida Y, Ohba Y, Alam MT, Kawamoto T, Ohmura H, Yamada K, Torii C, Shindoh M, Hida K.
Inhibition of Multidrug Transporter in Tumor Endothelial Cells Enhances Antiangiogenic Effects of Low-Dose Metronomic Paclitaxel.
Am J Pathol. 2014 Dec 8. pii: S0002-9440(14)00611-7. doi: 10.1016/j.ajpath.2014.10.017.
(Vascular Biology)

Ohoka, A., Kajita, M., Ikenouchi, J., Yako, Y., Kitamoto, S., Kon, S., Ikegawa, M., Shimada, T., Ishikawa, S., and Fujita, Y. (2014)
EPLIN is a crucial regulator for extrusion of RasV12-transformed cells.
Journal of Cell Science, in press
(Molecular Oncology)

Ohmura-Kakutani H, Akiyama K, Maishi N, Ohga N, Hida Y, Kawamoto T, Iida J, Shindoh M, Tsuchiya K, Shinohara N, Hida K.
Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype.
PLoS One. 2014 Dec 1;9(12):e113910. doi: 10.1371/journal.pone.0113910. eCollection 2014.
(Vascular Biology)

Alam MT, Nagao-Kitamoto H, Ohga N, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Taketomi A, Shindoh M, Hida Y, Hida K.
Suprabasin as a novel tumor endothelial cell marker.
Cancer Sci. 2014 Oct 5. doi: 10.1111/cas.12549.
(Vascular Biology)

Hosoya T, Sakai F, Yamashita M, Shiozaki T, Endo T, Ukibe K, Uenishi H, Kadooka Y, Moriya T, Nakagawa H, Nakayama Y, Miyazaki T.
Lactobacillus helveticus SBT2171 inhibits lymphocyte proliferation by regulation of the JNK signaling pathway.
PLoS One. 2014 Sep 30;9(9):e108360. doi: 10.1371/journal.pone.0108360. eCollection 2014.
(Probiotics Immunology)

Kudo H, Wada H, Sasaki H, Tsuji H, Otsuka R, Baghdadi M, Kojo S, Chikaraishi T, Seino K.
Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival.
PLoS One. 2014 Oct 30;9(10):e111826. doi: 10.1371/journal.pone.0111826.
eCollection 2014.
(Molecular Neuroimmunology)

Anton, K. A., Sinclair, J., Ohoka, A., Kajita, M., Ishikawa, S., Benz, P. M., Renne, T., Balda, M., Jorgensen, C., Matter, K., and Fujita, Y.
PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium.
J Cell Sci. 2014 Aug 15;127(Pt 16):3425-33.
(Molecular Oncology)

Kajita M, Sugimura K, Ohoka A, Burden J, Suganuma H, Ikegawa M, Shimada T, Kitamura T, Shindoh M, Ishikawa S, Yamamoto S, Saitoh S, Yako Y, Takahashi R, Okajima T, Kikuta J, Maijima Y, Ishii M, Tada M, Fujita Y.
Filamin acts as a key regulator in epithelial defence against transformed cells.
Nat Commun. 2014 Jul 31;5:4428
(Molecular Oncology)

Jinushi M.
Immune regulation of therapy-resistant niches: emerging targets for improving anticancer drug responses.
Cancer Metastasis Rev. 2014 Sep;33(2-3):737-45. doi: 10.1007/s10555-014-9501-9.

Yamashina T, Baghdadi M, Yoneda A, Kinoshita I, Suzu S, Dosaka-Akita H, Jinushi M.
Cancer stem-like cells derived from chemoresistant tumors have a unique capacity to prime tumorigenic myeloid cells.
Cancer Res. 2014 May 15;74(10):2698-709. doi: 10.1158/0008-5472.CAN-13-2169. Epub 2014 Mar 17.

Jinushi M.
Immune regulation of therapy-resistant niches: emerging targets for improving anticancer drug responses.
Cancer Metastasis Rev. 2014 Sep;33(2-3):737-45. doi: 10.1007/s10555-014-9501-9.

Hirose T, Mishima Y, Tomari Y.
Elements and machinery of non-coding RNAs: toward their taxonomy.
EMBO Rep. 2014 May;15(5):489-507. doi: 10.1002/embr.201338390. Epub 2014 Apr 14.
(RNA Biofunction)

Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T.
Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress.
Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3080-5. doi: 10.1073/pnas.1311022111. Epub 2014 Feb 10.

>>more