Rasmussen M, Alvik K, Kannen V, Olafsen NE, Erlingsson LAM, Grimaldi G, Takaoka A, Grant DM, Matthews J. Loss of PARP7 Increases Type I Interferon Signaling in EO771 Breast Cancer Cells and Prevents Mammary Tumor Growth by Increasing Antitumor Immunity. Cancers (Basel), 15, 3689-, 2023.
Kajihara N, Tanaka Y, Takeuchi R, Kobayashi T, Tanji M, Ataka T, Nakano S, Yamada T, Takaoka A, Hasegawa Y, Seino KI, Wada H. Augmented interferon regulatory factor 7 axis in whole tumor cell vaccines prevents tumor recurrence by inducing interferon gamma-secreting B cells. Oncoimmunology, 12, 2213132-, 2023.
Yamada T, Takaoka A. Essential role of Rnd1 in innate immunity during viral and bacterial infections. Inflamm Regen., 43, 7-, 2023.
Kumar A, Mishra S, Kumar A, Raut AA, Sato S, Takaoka A, Kumar H. Cancer cells deliver a suppressive cargo. Cell Death Dis., 13, 520-, 2022.
Hashizume S, Nakano M, Kubota K, Sato S, Himuro N, Kobayashi E, Takaoka A, Fujimiya M. Mindfulness intervention improves cognitive function in older adults by enhancing the level of miRNA-29c in neuron-derived extracellular vesicles. Sci Rep., 11, 21848-, 2021.
Baidya S, Nishimoto Y, Sato S, Shimada Y, Sakurai N, Nonaka H, Noguchi K, Kido M, Tadano S, Ishikawa K, Li K, Okubo A, Yamada T, Orba Y, Sasaki M, Sawa H, Miyamoto H, Takada A, Nakamura T, Takaoka A. Dual Effect of Organogermanium Compound THGP on RIG-I-Mediated Viral Sensing and Viral Replication during Influenza a Virus Infection. Viruses, 13, 1674-, 2021.
Yamada T, Sato S, Sotoyama Y, Orba Y, Sawa H, Yamauchi H, Sasak M, Takaoka A. RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells. Nat. Immunol., 22, 820-828, 2021. (http://dx.doi.org/10.1038/s41590-021-00942-0)
Jeremiah, SS, Miyakawa, K, Matsunaga S, Nishi M, Kudoh A, Takaoka A, Sawasaki T, Ryo A. Cleavage of TANK-Binding Kinase 1 by HIV-1 Protease Triggers Viral Innate Immune Evasion. Front. Microbiol., 27 April 2021 | https://doi.org/10.3389/fmicb.2021.643407.
Sato S, Li K, Sakurai N, Hashizume M, Baidya S, Nonaka H, Noguchi K, Ishikawa K, Obuse C, Takaoka A. Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections. Cell Immunol., 356, 104188, 2020.
Hamada-Tsutsumi S, Naito Y, Sato S, Takaoka A, Kawashima K, Isogawa M, Ochiya T, Tanaka Y. The antiviral effects of human microRNA miR-302c-3p against hepatitis B virus infection. Aliment Pharmacol Ther., 49, 1060-1070, 2019.
Hashizume M, Aoki K, Ohno S, Kitaichi N, Yawata N, Gonzalez G, Nonaka H, Sato S, Takaoka A. Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate. Eur J Ophthalmol., 2019 Dec 9;1120672119891408. doi: 10.1177/1120672119891408.
Takaoka A, Yamada T. Regulation of signaling mediated by nucleic acid sensors for innate interferon-mediated responses during viral infection. Int. Immunol., 31, 477-488, 2019.
Suzuki H, Kameyama T, Takaoka A. BinCARD2 as a positive regulator of interferon response in innate immunity. Biochem Biophys Res Commun. , 511, 287-293, 2019.
Kumar A, Kumar A, Ingle H, Kumar S, Mishra R, Verma MK, Biswas D, Kumar NS, Mishra A, Raut AA, Takaoka A, Kumar H. MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2. J. Virol., 92, e01057-18, 2018.
Takaoka A. Cancer cells deliver a suppressive cargo. Nat. Immunol., 19, 207-208, 2018.
Sakamoto A, Matsuda T, Kawaguchi K, Takaoka A, Maruyama M. Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM. Int. Immunol., 29, 431-438, 2017.
Kumari P, Saha I, Narayanan A, Narayanan S, Takaoka A, Kumar NS, Tailor P, Kumar H.
Essential role of HCMV deubiquitinase in promoting oncogenesis by targeting anti-viral innate immune signaling pathways. Cell Death Dis., 8, e3078, 2017.
YLi MM, Lau Z, Cheung P, Aguilar EG, Schneider WM, Bozzacco L, Molina H, Buehler E, Takaoka A, Rice CM, Felsenfeld DP, MacDonald MR. TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). PLoS Pathog., 173, e1006145, 2017.
Yamada T, Horimoto H, Kameyama T, Hayakawa S, Yamato H, Dazai M, Takada A, Kida H, Bott D, Zhou AC, Hutin D, Watts TH, Asaka M, Matthews J, Takaoka A. Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense. Nat. Immunol., 17, 687-94, 2016.
Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A. Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage. Immunity. 43, 974-86, 2015.
Ingle H, Kumar S, Raut AA, Mishra A, Kulkarni DD, Kameyama T, Takaoka A, Akira S, Kumar H. The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication. Sci. Signal.. 8(406):ra126, 2015.
Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice CM, Harashima H, Kohara M, Tanaka Y, Takaoka A. The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus. Immunity, 42, 123-132, 2015.
Kumar S, Ingle H, Mishra S, Mahla RS, Kumar A, Kawai T, Akira S, Takaoka A, Raut AA, Kumar H.
IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity. Cell Death Dis. 2015 May 7;6:e1758.
Stimulation of Macrophages with the β-Glucan Produced by Aureobasidium
pullulans Promotes the Secretion of Tumor Necrosis Factor-Related Apoptosis
Inducing Ligand (TRAIL).Kawata K, Iwai A, Muramatsu D, Aoki S, Uchiyama
H, Okabe M, Hayakawa S, Takaoka A, Miyazaki T.PLoS One. 10, e0124809, 2015.
Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T,
Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T,
Rice CM, Harashima H, Kohara M, Tanaka Y, Takaoka A. The RNA Sensor RIG-I
Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis
B Virus. Immunity, Published online: December 31, 2014
Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons
S, Ishii M, Sheppard D, Takaoka A, Uede T. Integrin α9 on lymphatic endothelial
cells regulates lymphocyte egress. Proc Natl Acad Sci U S A. 2014 Feb 10. [Epub ahead of print]
Jinushi M, Chiba S, Baghdadi M, Kinoshita I, Dosaka-Akita H, Ito K, Yoshiyama H, Yagita H, Uede T, Takaoka A.ATM-mediated DNA damage signals mediate immune escape through integrin αvβ3-dependent mechanisms.Cancer Res.2011 Nov 17.
Hayakawa, S., Shiratori, S., Yamato, H., Kameyama, T., Kitatsuji, C., Kashigi, F., Goto, S., Kameoka, S., Fujikura, D., Yamada, T., Mizutani, T., Kazumata, M., Sato, M., Tanaka, J., Asaka, M., Ohba, Y., Miyazaki, T., Imamura, M. and Takaoka, A.ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses.Nat. Immunol.,12, 37-44, 2011.
Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H.Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells.Proc Natl Acad Sci U S A.108, 12425-30, 2011.
Sasaki S, Ishida T, Toyota M, Ota A, Suzuki H, Takaoka A, Yasui H, Yamamoto H, Takagi H, Maeda M, Seito T, Tsujisaki M, Shinomura Y, Imai K.Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo.PLoS One6, e19618, 2011.
Tsushima K, Osawa T, Yanai H, Nakajima A, Takaoka A, Manabe I, Ohba Y, Imai Y, Taniguchi T, Nagai R.IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension.FASEB J. 25, 1531-43, 2011.
Chen, H.M., Tanaka, N., Mitani, Y., Oda, E., Nozawa, H., Chen, J.Z., Yanai, H., Negishi, H., Choi, M.K., Iwasaki, T., Yamamoto, H., Taniguchi, T., and Takaoka, A.Critical role for constitutive type I interferon gnaling in the prevention of cellular transformation.Cancer Sci.100, 449-456, 2009.
Wang, Z., Choi, M.K., Ban, T., Yanai, H., Negishi, H., Lu, Y., Tamura, T., Takaoka, A., Nishikura, K., and Taniguchi, T.Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.Proc. Natl. Acad. Sci. USA, 105, 5477-5482, 2008.
Takaoka, A., and Taniguchi, T.Cytosolic DNA recognition for triggering innate immune responses.Advanced Drug Delivery Reviews, 60, 847-857, 2008.
Takaoka, A., Tamura, T., and Taniguchi, T.IRF family of transcription factors and regulation of oncogenesis.Cancer Sci., 99, 467-478, 2008.
Takaoka, A., Wang, Z., Choi, M.K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K., Ohba, Y., and Taniguchi, T.DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.Nature , 448, 501-505, 2007.
Yanai, H., Chen, H., Inuzuka, T., Kondo, S., Mak, W. T., Takaoka. A., Honda, K. and Taniguchi, T.Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.Proc. Natl. Acad. Sci. USA, 104, 3402-3407, 2007.
Imai, K., and Takaoka, A.Comparing antibody and small-molecule therapies for cancer.Nat. Rev. Cancer, 6, 714-727, 2006.
Takaoka, A., and Yanai, H.Interferon signalling network in innate defence.Cell. Microbiol., 8, 907-922, 2006.
Shibue, T., Suzuki, S., Okamoto, H., Yoshida, H., Ohba, Y., Takaoka, A., and Taniguchi, T.Differential contribution of Puma and Noxa in dual regulation of p53-dependent apoptotic pathways.EMBO. J., 25, 4952-4962, 2006.
Honda, K., Takaoka, A., and Taniguchi, T.Type I interferon gene induction by the interferon regulatory factor family of transcription factors.Immunity, 25, 349-60, 2006.
Yanai H., Mizutani T., Inuzuka T., Honda K., Takaoka A. and Taniguchi T.IRF family transcription factors in type I interferon induction.Int. Congress Series, 1285, 104-113, 2005.
Honda K., Yanai H., Takaoka A., and Taniguchi T.Regulation of the type I IFN induction: a current view.Int. Immunol., 17, 1367-1378, 2005.
Negishi H., Ohba Y., Yanai H., Takaoka A., Honma K., Yui K., Matsuyama T., Taniguchi T., and Honda K.Negative regulation of Toll-like-receptor signaling by IRF-4.Proc. Natl. Acad. Sci. USA., 102, 15989-15994, 2005.
Takayanagi H., Sato K., Takaoka A., and Taniguchi T.Interplay between interferon and other cytokine systems in bone metabolism.Immunol. Rev., 208, 181-193, 2005.
Honda K., Ohba, Y., Yanai, H., Negishi, H., Mizutani, T., Takaoka, A., Taya, C., and Taniguchi, T.Spatiotemporal regulation of MmyD88-IRF-7 signalling for robust type I interferon induction.Nature, 434, 1035-1040, 2005.
Honda K., Yanai H., Negishi H., Asagiri M., Sato M., Mizutani T., Shimada N., Ohba Y., Takaoka A., Yoshida N., and Taniguchi T.IRF-7 is the master regulator of type-I interferon-dependent immune responses.Nature, 434, 772–777, 2005.
Takaoka A., Yanai H., Kondo S., Duncan G., Negishi H., Mizutani T., Kano S., Honda K., Ohba Y., Mak T.M., and Taniguchi T.Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.Nature, 434, 243-249, 2005.
Taniguchi, T., and Takaoka, A.Type I interferon system and IRF family of transcription factors in host defense regulation.Proc. Jpn. Acad., 81, 1-13, 2005.
Honda, K., Yanai, H., Mizutani, T., Negishi, H., Shimada, N., Suzuki, N., Ohba, Y., Takaoka, A., Wen-Chen Yeh, and Taniguchi, T.Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.Proc. Natl. Acad. Sci. USA, 101, 15416-15421, 2004.
Takaoka, A. and Taniguchi, T.New aspects of IFN-alpha/beta signalling in immunity, oncogenesis and bone metabolism.Gann Monograph on Cancer Research, 52, 141-156, 2004.
Honda, K., Sakaguchi, S., Nakajima, C., Watanabe, A., Yanai, H., Matsumoto, M., Ohteki, T., Kaisho, T., Takaoka, A., Akira, S., Seya, T., and Taniguchi, T.Selective contribution of IFN-a/b signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.Proc. Natl. Acad. Sci. USA , 100, 10872-10877, 2003.
Shibue, T., Takeda, K., Oda, E., Tanaka, H., Murasawa, H., Takaoka, A., Morishita, Y., Akira, S., Taniguchi, T., and Nobuyuki Tanaka, N.Integral role of Noxa in p53-mediated apoptotic response.Genes. Dev., 17, 2233-2238, 2003.
Takaoka, A., Hayakawa, K., Yanai, H., Stoiber, D., Negishi, H., Kikuchi, H., Shibue, T., Honda, K., and Taniguchi, T.Integration of IFN-a/b signalling to p53 responses in tumor suppression and antiviral defense.Nature, 424, 516-523, 2003.
Sakaguchi, S., Negishi, H., Asagiri, M., Nakajima, C., Mizutani, T., Takaoka, A., Honda, K., and Taniguchi, T.Essential role of IRF-3 in lipopolysaccharide-induced interferon-β gene expression and endotoxin shock.Biochem Biophys Res Commun, 306, 806-866, 2003.
Takaoka, A., and Taniguchi, T.New aspects of IFN-α/βsignaling in immunity, oncogenesis and bone metabolism.Cancer Science, 94, 405-411, 2003.
Taniguchi, T., Takaoka, A.Interferon-α/β system in antiviral response: Multimodal machinery of gene regulation by the IRF family of transcription factors.Curr. Opin. Immunol., 14, 111-116, 2002.
Mitani, Y., Takaoka, A., Kim, S. H., Kato, Y., Yokochi, T., Tanaka, N., and Taniguchi, T.Cross talk of the interferon-α/β signaling complex with gp130 for effective interleukin-6 signaling.Genes to Cells, 6, 631-640, 2001.
Hata, N. Sato, M. Takaoka, A. Asagiri, M. Tanaka, N. Taniguchi, T.Constitutive IFN-α/β signal for efficient IFN-α/β gene induction by virus.Biochem Biophys Res Commun, 285, 518-525, 2001.
Taniguchi, T. and Takaoka, A.A weak signal for strong responses: Interferon-α/β Revisited.Nature Rev. Mol. Cell Biology, 2, 378-386, 2001.
Taniguchi, T., Ogasawara, K., Takaoka, A, and Tanaka, N.IRF family of transcription factors as regulators of host defense.Ann. Rev. Immunol., 19, 623-655, 2001.
Takayanagi, H., Ogasawara, K., Hida, S., Chiba, T., Murata, S., Sato, K., Takaoka, A., Yokochi, T., Oda, H., Tanaka, K., Nakamura, k. and Taniguchi, T.T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ.Nature, 408, 600-605, 2000.
Tsujino, S., Di Santo, J. P.,Takaoka, A., Mckernan,T. L., Noguchi, S., Taya, C., Yonekawa, H., Saito, T., Taniguchi, T., and Fujii, H.Differential requirement of the cytoplasmic subregions of γ c chain in T cell development and function.Proc. Natl. Acad. Sci. USA, 97, 10514-10519, 2000.
Takaoka, A., Mitani, Y., Suemori, H., Sato, S., Yokochi, T., Noguchi, S., Tanaka, N., and Taniguchi, T.Crosstalk between interferon-γ and-α/β signaling components at caveolar membrane domain.Science, 288, 2357-2360, 2000.
Taniguchi, T., Tanaka, N., Ogasawara, K., Taki, S., Sato, M. and Takaoka, A.The transcription factor IRF-1 and its family members in the regulation of host defense.Cold Spring Harbor Symposia on Quantitative Biology, 64, 465-472, 1999.
Taniguchi, T., Tanaka, N., Ogasawara, K., Hida, S., Sato, M. and Takaoka, A.Regulation of interferon and immune systems by the IRF family of transcription factors.J. Interferon and Cytokine Res., 19(Sup. 1), S55, 1999.
Takaoka, A., Tanaka, N., Mitani, Y., Miyazaki, T., Fujii, H., Sato, M., Kovarik, P,. Decker, T., Schlessinger, J. and Taniguchi, T.Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in the IFN-γ, but not IFN-α, signaling.EMBO. J., 18, 2480-2488, 1999.
Takaoka, A., Hinoda, Y., Sato, S., Adachi, Y., Itoh, F., Adachi, M., and Imai, K.Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene.Oncogene, 16, 1443-1453, 1998.
Takaoka, A., Hinoda, Y., Sato, S., Itoh, F., Adachi, M., and Imai, K. Reduced invasive and metastatic potentials of KAI1-transfected melanoma cells. Jpn. J. Cancer Res., 98, 397-404, 1998.
Hinoda, Y., Adachi, Y., Takaoka, A., Mitsuuchi, H., Satoh, Y., Itoh, F., Kondoh, Y., and Imai, K. Decreased expression of the metastasis suppressor gene KAI1 in gastric cancer. Cancer Lett., 129, 229-234, 1998.
Miyazaki, T., Takaoka, A., Noguerira, L., Dikic, I., Fujii, H., Tsujino, S., Mitani, Y., Maeda, M., Schlessinger, J. and Taniguchi, T.Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak-signaling pathway.Genes. Dev., 12, 770-775, 1998.
Takaoka, A., Toyota, M., Hinoda, Y., Itoh, F., Mita, H., Kakiuchi, H., and Imai, K.Expression and identification of aberrant c-kit transcripts in human cancer cells.Cancer Lett., 115, 257-261, 1997.
Takaoka, A., Adachi, M., Okuda, H., Sato, S., Yawata, A., Hinoda, Y., Takayama, S., Reed, J.C., and Imai, K.Anti-cell death activity promotes pulmonary metastasis of melanoma cells.Oncogene, 14, 2971-2977, 1997.
Toyota, M., Hinoda, Y., Nakagawa, N., Arimura, Y., Tokuchi, S., Takaoka, A., Kitagawa, S., Usuki, T., Yabana, T., Yachi, A., and Imai, K.Gastric antral vascular ectasia causing severe anemia. J. Gastroenterol.J. Gastroenterol., 31, 710-713, 1996.
Toyota, M., Hinoda, Y., Itoh, F., Takaoka, A., Imai, K., and Yachi, A.Complementary DNA cloning and characterization of truncated form of c-kit in human colon carcinoma cells.Cancer Res., 54, 272-275, 1994.
Toyota, M., Hinoda, Y., Takaoka, A., Makiguchi, Y., Takahashi, T., Itoh, F., Imai, K., and Yachi, A.Expression of c-kit and kit ligand in human colon carcinoma cells.Tumour Biol., 14, 295-302, 1993.
Nishi, M., Miyake, H., Ito, Y., Kagiichi, S., Kimura, M., Suzuki, A., Takaoka, A., Tago, N., and Nagase, K.Uptake of immunization of children with asthma.Acta. Paediatr. Jpn., 32, 328-329, 1990.
Nishi, M., Miyake, H., Ito, Y., Kagiichi, S., Kimura, M., Suzuki, A., Takaoka, A., Tago, N. and Nagase, K.Vaccination of children in Japan.Asia. Pac. J. Public Health.l., 4, 128-131, 1990.