インフルエンザの病態形成における
アポトーシス誘導制御MECHANISM OF APOPTOSIS INDUCTION AND PATHOGENESIS OF INFLUENZA
いろいろなプロバイオティクス菌株による感染症、癌、アレルギー、炎症性疾患の予防・治療効果をマウスの疾患モデルを用いて評価し、効果のある菌株を選択し、その生菌と死菌の効果の違いと機能を評価します。さらにその菌体画分あるいは産生物の成分分析をし物質を同定します。その物質による腸管免疫系の免疫細胞活性化や細胞遊走・接着およびサイトカイン産性能および腸内フローラへの影響を調べます。
それらの効果や機能が認められた場合、応答する細胞やその物質の受容体、刺激因子を明らかにし、細胞増殖、アポトーシスや細胞遊走の誘導シグナル伝達経路を解析します。これまで私たちが解析してきたアポトーシス誘導分子や老化・寿命制御遺伝子の発現変化を調べ、それらの発現制御および細胞内会合や局在変化による機能調節機構を解明し、プロバイオティクスの疾病予防・治療への応用を目指します。
We evaluate and observe how probiotics affect various diseases, including infectious diseases, cancer and allergies. We are also interested in probiotics for the prevention and treatment of inflammatory diseases. In conducting our research, we choose the most effective bacteria and, using mice as test subjects, we then compare the outcome and functions of two types of bacteria: living-bacteria and dead-bacteria. We observe the features of the probiotics and analyze/identify the components that are produced. We then investigate the influence of the probiotics on cytokine, intestinal flora and the immunity cell activation, proliferation, adhesion of intestinal immunity.
Where a reaction is seen to have taken place, we try to identify the responding cell, the receptor of the substance, the stimulating factor and analyze the inducement signal transmitting route of the planocyte and apoptosis. We aim to use probiotics in disease prevention and treatment through our research into the apoptosis induction molecule, and the aging and lifespan control gene. We also examine the difference in appearance between them, working to reveal their appearance control, the functional adjustment mechanism of intracellular association and any altered localization.