■研究業績

幹細胞生物学分野　近藤　亨

【研究論文】
  1. Yamashita, D., Kondo, T., Ohue, S., Takahashi, H., Ishikawa, M., Matoba, R., Suehiro, S., Kohno, S., Harada, H., Tanaka, J., & Ohnishi, T. (2015). miR-340 acts as a tumor suppressor in tumorigenesis of human glioblastoma-initiating cells by targeting plasminogen activator, tissue. Cancer Res. 75, 1123-1133.
  2. Morita, R., Nishizawa, S., Torigoe, T., Takahashi, A., Tamura, Y., Tsukahara, T., Kanaseki, T., Sokolovskaya, A., Kochin, V., Kondo, T., Hashino, S., Asaka, M., Hara, I., Hirohashi, Y., & Sato, N., (2014). Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells. Cancer Sci. 105, 389-395.
  3. Dellett, M., Sasai, N., Nishide, K., Becher, S., Papadaki, V., Limb, G. A., Moore, A.T., Kondo, T., & Ohnuma, S.I. (2014). Genetic background and light-dependent progression of photoreceptor cell degeneration in prominin-1 knockout mice. Invest. Ophthalmol. Vis. Sci. 56, 164-176.
  4. Takahashi, A., Hirohashi, Y., Torigoe, T., Tamura, Y., Tsukahara, T., Kanaseki, T., Kochin, V., Saijo, H., Kubo, T., Nakatsugawa, M., Asanuma, H., Hasegawa, T., Kondo, T., & Sato, N. (2013). Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells. PLoS ONE 8, e69095.
  5. Deshmukh, VA., Tardif, V., Lyssiotis, CA., Green, CC., Kerman, B., Kim, HJ., Padmanabhan, K., Swoboda, JG., Ahmed, I., Kondo, T., Gage, FH., Theofilopoulos, AN., Lawson, BR., Schultz, PG., & Lairson, LL.. (2013). A Regenerative Approach to the Treatment of Multiple Sclerosis. Nature 502, 327-332.
  6. Yamada, R., Takahashi, A., Torigoe, T., Morita, R., Tamura, Y., Tsukahara, T., Kanaseki, T., Kubo, T., Watarai, K., Kondo, T., Hirohashi, Y., & Sato, N.
  7. (2013). Preferential expression of cancer/testis (CT) genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem
  8. (CTS) gene. Tissue Antigens 81, 428-434.
  9. Morita, R., Hirohashi, Y., Suzuki, H., Takahashi, A., Tamura, Y., Kanaseki, T., Asanuma, H., Inoda, S., Kondo, T., Hashino, S., Hasegawa, T., Tokino, T., Toyota, M., Asaka, M., Torigoe, T., & Sato, N. (2013). DNA methyltransferase 1 is essential for initiation of the colon cancers. Exp. Mol. Pathol. 94, 322-329.
  10. Nishizawa, S., Hirohashi, Y., Torigoe, T., Takahashi, A., Tamura, Y., Mori, T., Kanaseki, T., Kamguchi, K., Asanuma, H., Morita, R., Sokolovskaya, A., Matsuzaki, J., Yamada, R., Fujii, R., Kampinga, HH., Kondo, T., Hasegawa, T., Hara, I., & Sato, N. (2012). HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells. Cancer Res. 72, 2844-2854.
  11. Mori, T., Nishizawa, S., Hirohashi, Y., Torigoe, T., Tamura, Y., Takahashi, A., Kochin, V., Fujii, R., Kondo, T., Greene, M.I., Hara, I., & Sato, N. (2012). Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population. Exp. Mol. Pathol. 92, 27-32.
  12. Nakatsugawa, M., Takahashi, A., Hirohashi, Y., Torigoe, T., Inoda, S., Asanuma, H., Tamura, Y., Morita, R., Michifuri, Y., Kondo, T., Hasegawa, T., Takahashi, H., & Sato, N. (2011). SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity. Lab. Invest. 91, 1796-1804.
  13. Choijamts, B., Jimi, S., Kondo, T., Naganuma, Y., Kuroki, M., Miyamoto, S., Iwasaki, H., & Emoto, M. (2011). CD133+ cells contain cancer stem cell-like properties in Carcinosarcoma (Malignant Mixed Mullerian Tumor) of the Uterus. Stem Cells 29, 1485-1495.
  14. Takezaki, T., Hide, T., Takanaga, H., Nakamura, H., Kuratsu, J., & Kondo, T. (2011). Essential role of the Hedgehog signaling pathway in human glioma-initiating cells. Cancer Science 102, 1306-1312.
  15. Hide, T., Takezaki, T., Nakatani, Y., Nakamura, H., Kuratsu, J., & Kondo, T. (2011). Combination of a Ptgs2 inhibitor and an EGFR signaling inhibitor prevents tumorigenesis of oligodendrocyte-lineage derived glioma-initiating cells. Stem Cells 29, 590-599.
  16. Inoda, S., Hirohashi, Y., Torigoe, T., Morita, R., Takahashi, A., Asanuma, H., Nakatsugawa, M., Nishizawa, S., Tamura, Y., Tsuruma, T., Terui, T., Kondo, T., Ishitani, K., Hasegawa, T., Hirata, K., & Sato, N. (2011). Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. Am. J. Pathol. 178, 1805-1813.
  17. Sumitomo, A., Ishino, R., Urahama, N., Inoue, K., Yonezawa1, K., Hasegawa, N., Horie, O., Matsuoka, H., Kondo, T., Roeder, R.G., & Ito, M. (2010). Transcriptional Mediator Subunit MED1/TRAP220 in Stromal 1 Cells Is Involved in Hematopoietic Stem/Progenitor Cell Support through Osteopontin Expression. Mol. Cell Biol. 30, 4808-4817.
  18. Kujuro, Y., Suzuki, N., & Kondo, T. (2010). Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed in aged CNS precursor cells. Proc. Natl. Acad. Sci. USA. 107, 8259-8264.
  19. Murase, M., Kano, M., Tsukahara, T., Takahashi, A., Torigoe, T., Kawaguchi, S., Kimura, S., Wada, T., Uchihashi, Y., Kondo, T., Yamashita, T., & Sato, N. (2009). Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas. Br. J. Cancer 101, 1425-1432.
  20. Hide, T., Takezaki, T., Nakatani, Y., Nakamura, H., Kuratsu, J., & Kondo, T. (2009). Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Cancer Res. 69, 7953-7959.
  21. Nishide, K., Nakatani, Y., Kiyonari, H., & Kondo, T. (2009). Gliomagenesis from transformed neural stem cells depleted of prominin1-expressing cells. PLoS ONE 4, e6869.
  22. Takanaga, H., Tsuchida-Straten, N., Nishide, K., Watanabe, A., Aburatani, H., & Kondo, T. (2009). Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells. Stem Cells 27, 165-174.
  23. Hampton, D.W., Asher, R.A., Kondo, T., Steeves, J.D., Ramer, M.S., & Fawcett, J.W. (2007). A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult CNS injury in vivo. Eur. J. Neurosci. 26,@3024-3035.
  24. Lyssiotis, C.A., Walker, J., Wu, C., Kondo, T., Schultz, P.G., & Wu, X. (2007). Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte progenitor cells. Proc. Natl. Acad. Sci. USA 104, 14982-14987.
  25. Marin-Husstege, M., He, Y., Li, J., Kondo, T., Sablitzky, F., & Casaccia-Bonnefil, P.
    (2006). The phenotypic analysis of the oligodendrocyte lineage in Id4-deficient mice: predicted outcomes and unexpected findings. Glia 54, 285-296.
  26. Bedford, L., Walker, R., Kondo, T., van Cruchten, I., King, E.R., & Sablitzky, F. (2005).
    Id4 is required for the correct timing of neural differentiation. Dev. Biol. 280, 386-395.
  27. Kondo, T.*, & Raff, M. (2004b). Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells. Genes Dev. 18, 2963-2972. (*corresponding author)
  28. Setoguchi, T.#, & Kondo, T.*# (2004). Nuclear export of OLIG2 in neural stem cells is essential for CNTF-induced astrocyte differentiation. J. Cell Biol. 166, 963-968. (#equal contribution, *corresponding author)
  29. Kondo, T.*, & Raff, M.C. (2004a). A role for Noggin in the development of oligodendrocyte precursor cells. Dev. Biol. 267, 242-251. (*corresponding author)
  30. Fukuda, S.#, Kondo, T.#*, Takebayashi, H., & Taga, T.* (2004). Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2 on the astrocytic differentiation pathway. Cell Death Differ. 11, 196-202. (#equal contribution, *corresponding author)
  31. Kondo, T.*, Setoguchi, T., & Taga, T. (2004). Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc. Natl. Acad. Sci. USA 101, 781-786. (*corresponding author)
  32. Kondo, T.*, & Raff, M. (2000c). Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289, 1754-1757. (*corresponding author)
  33. Kondo, T.*, & Raff, M. (2000b). Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation. Development 127, 2989-2998. (*corresponding author)
  34. Kondo, T.*, & Raff, M. (2000a). The Id4 HLH protein and the timing of oligodendrocyte differentiation. EMBO J. 19, 1998-2007. (*corresponding author)
  35. Eguchi, A., Kondoh, T., Kosaka, H., Suzuki, T., Momota, H., Masago, A., Yoshida, T., Taira, H., Ishii-Watabe, A., Okabe, J., Hu, J., Miura, N., Ueda, S., Suzuki, Y., Taki, T., Hayakawa, T., & Nakanish, M. (2000). Identification and characterization of cell lines with a defect in a post-adsorption stage of Sendai virus-mediated membrane fusion. J. Biol. Chem. 275, 17549-17555.
  36. Mizuguchi, H., Nakagawa, T., Morioka, Y., Imazu, S., Nakanishi, M., Kondo, T., Hayakawa, T. & Mayumi, T. (1997). Cytoplasmic gene expression system enhances the efficiency of cationic liposome-mediated in vivo gene transfer into mouse brain. Biochem. Biophys. Res. Commun. 234, 15-18.
  37. Kondo, T., Yokokura, T. & Nagata, S. (1997). Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells. Proc. Natl. Acad. Sci. USA 94, 11951-11956.
  38. Kondo, T., Suda, T., Fukuyama, H., Adachi, M. & Nagata, S. (1997). Essential roles of the Fas ligand in the development of hepatitis. Nat. Med. 3, 409-413.
  39. Kato, A., Sakai, Y., Shioda, T., Kondo, T., Nakanishi, M. & Nagai, Y. (1996). Initiation of Sendai virus multiplication from transfected viral RNA or cDNA with negative or positive sense. Genes Cells 1, 569-579.
  40. Adachi, M., Suematsu, S., Kondo, T., Ogasawara, J., Tanaka, T., Yoshida, N. & Nagata, S. (1995). Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat. Genet. 11, 294-299.
  41. Tomita, N., Higaki, J., Ogihara, T., Kondo, T. & Kaneda, Y. (1994). A novel gene-transfer technique mediated by HVJ (Sendai Virus), nuclear protein, and liposomes. Can. Det. and Prev. 18, 485-491.
  42. Kondo, T., Yoshida, T., Miura, N. & Nakanishi, M. (1993). Temperature-sensitive phenotype of a mutant sendai virus strain is caused by its insufficient accumulation of the M protein. J. Biol. Chem. 268, 21924-21930.
【レビュー、図書】
  1. 近藤　亨 (2014). 神経膠芽腫幹細胞とマイクロRNA。医学のあゆみ、250、40-44.
  2. Kondo T. (2013). Molecular markers of glioma initiating cells. Inflamation and Regeneration 33, 181-189.
  3. 近藤　亨 (2013). グリオーマ幹細胞特異的因子群を標的とした新規治療法の開発。次世代がん戦略研究update がん基盤生物学ー革新的シーズ育成に向けてー、南山堂、29-34.
  4. 近藤　亨 (2013). 癌幹細胞を標的とした治療のこれからーグリオーマ幹細胞をモデルとして、Frontiers in Gastroenterology、メディカルレビュー社、 18、68―73.
  5. 近藤　亨 (2012). グリオーマ。モデル動物利用マニュアル「疾患モデルの作製と利用－がん」、エル・アイ・シー社、611-617.
  6. 近藤　亨 (2012). オリゴデンドロサイト前駆細胞。細胞工学、31, 7.
  7. Kondo T. (2011). Stem cells and cancer stem cells –new insights. Advances in Cancer Stem Cell Biology (edited by R. Scatena, A. Mordente, B. Giardina). 17-31. Springer
  8. Kondo T. (2011). Tumorigenesis of glioma-initiating cells: Role of Sox11. Stem Cells and Cancer Stem Cells (edited by M.A. Hayat). Vol. 1. 93-98, Springer.
  9. 近藤　亨 (2011). グリオーマ。臨床検査　55, 477-482.
  10. 近藤　亨 (2011). 脳腫瘍のCSC。BIO Clinica、26, 39-43.
  11. 近藤　亨 (2011). 脳腫瘍の癌幹細胞治療戦略。医薬ジャーナル、47, 103-108.
  12. 近藤　亨 (2010). カラー図説：癌幹細胞と分子標的薬。固形癌の最新治療—癌治療への新たな取り組みー　日本臨床社　68, 986-990.
  13. 近藤　亨 (2010). 人工グリオーマからの考察。再生医療、メディカルレビュー社　9, 42-46.
  14. Kondo T. (2010). Mouse induced glioma-initiating cell models and therapeutic targets. Anticancer agents Med. Chem. 10, 471-480.
  15. 近藤　亨 (2010). 幹細胞生物学からみた脳腫瘍の発生機序。新時代の脳腫瘍学—診断・治療の最前線—　日本臨床社 増刊号　68, 24-28.
  16. 近藤　亨 (2010). 膠芽腫。Clinical Neuroscience 28, 1419-1421.
  17. 近藤　亨 (2009). グリオーマ幹細胞。脳21 12, 11-15. 　
  18. 近藤　亨 (2009). 脳腫瘍における癌幹細胞。実験医学別冊　癌と微小環境　36-42.
  19. 近藤　亨 (2009). 癌幹細胞マーカー。Surgery Frontier　16, 15-20.
  20. 近藤　亨 (2009). 癌幹細胞。炎症・再生医学事典　426-429、朝倉書店.
  21. 近藤　亨 (2009). オリゴデンドロサイトの分化制御機構とオリゴデンドログリオーマの発生。Brain and Nerve　61, 741-751.
  22. 近藤　亨（2009). グリオーマ幹細胞。Medical Science Digest　35, 18-21.
  23. Kondo T. (2008). Stem cell-like glioma cells. Current cancer therapy Review 4, 201-205.
  24. 近藤　亨 (2008). ガン幹細胞マーカー。Cancer Frontier 10, 21-25.
  25. 近藤　亨 (2008). グリオーマ起源細胞。Clinical neuroscience 26, 882-883.
  26. 近藤　亨 (2008). 幹細胞様グリオーマ細胞。医学のあゆみ 227, 43-47.
  27. 近藤　亨 (2008). 固形がんにおけるがん幹細胞研究の進展。血液・腫瘍化 56, 689-693.
  28. 近藤　亨 (2008). グリオーマ幹細胞。細胞 40, 12-15.
  29. 近藤　亨 (2008). 癌幹細胞¬−癌研究のフロンティア。実験医学　26, 1194-1199.
  30. 秀拓一郎、近藤　亨 (2008). 脳腫瘍「癌幹細胞」研究の現状。実験医学 26, 1225-1231.
  31. 近藤　亨 (2008). 神経細胞分化と可塑性。シリーズ脳科学4、脳の発生と発達　187-224、東京大学出版.
  32. Hide T, Takezaki T, Nakamura H, Kuratsu J, & Kondo, T. (2008). Brain tumor stem cells as research and treatment targets. Brain Tumor Pathol. 25, 67-72.
  33. Kondo T. (2008). Making of glioma-initiating cells. Inflamation and Regeneration 28, 537-542.
  34. 近藤　亨 (2007). 幹細胞様ガン細胞。細胞工学 26, 523-526.
  35. 近藤　亨 (2007). 腫瘍発生とエピジェネテック。分子細胞治療 6, 30-34.
  36. Kondo T. (2007). Stem cell-like cancer cells in cancer cell lines. Cancer Biomarkers 3, 245-250.
  37. Kondo T. (2007). Stem cell-like cancer cells in cancer cell lines. Inflamation and Regeneration 27, 506-511.
  38. 近藤　亨 (2006). オリゴデンドロサイト前駆細胞の脱分化とエピジェネティクス変化。実験医学別冊、 羊土社 24, 83-88.
  39. 近藤　亨 (2006). 癌幹細胞の単離と制御シグナル〜真の癌幹細胞分離へのアプローチ。実験医学、 羊土社 24, 403-408.
  40. 近藤　亨 (2006). 脳腫瘍に内在する幹細胞様細胞。再生医療、メディカルレビュー社 5, 72-78.
  41. Kondo T. (2006). Brain cancer stem-like cell. Eur. J. Oncol. 42, 1237-1242.
  42. Kondo T. (2006). Epigenetic alchemy for cell fate conversion. Curr. Opin. Genet. Dev. 16, 502-507.
  43. 近藤　亨 (2006). 幹細胞様ガン細胞。Cancer Frontier 8, 54-60.
  44. 近藤　亨 (2006). グリオーマ細胞株に存在する幹細胞様細胞。医学のあゆみ 219, 195-198.
  45. 近藤　亨 (2004). オリゴデンドロサイト前駆細胞の可塑性。実験医学、羊土社　22, 23-28.
  46. Setoguchi, T., Taga, T., and Kondo, T.* (2004). Cancer stem cells persist in many cancer cell lines. Cell Cycle, 3, 414-415. (*corresponding author)
  47. 近藤　亨 (2002). 神経幹細胞の分化制御機構。炎症と免疫、先端医学社 10, 19-24.
  48. 近藤　亨 (2002). グリア前駆細胞の可塑性。Clinical neuroscience、中外医学社 20, 45-48.
  49. 近藤　亨 (2002). ラットオリゴデンドロサイト前駆細胞の単離法。クローズアップ実験法総集編、実験医学別冊、羊土社　178-183.
  50. 近藤　亨 (2002). オリゴデンドロサイトの発生を制御する細胞内在時計。医学のあゆみ、医歯薬出版 201, 351-355.
  51. 近藤　亨 (2002). 組織幹細胞の可塑性。再生医学・再生医療、現代化学増刊、東京化学同人 29-33.
  52. 近藤　亨 (2002). オリゴデンドロサイトの分化制御とその可塑性。分子細胞治療、先端医学社 1, 40-45.
  53. 近藤　亨 (2001). オリゴデンドロサイトの発生を制御する“細胞時計”。蛋白質核酸酵素、共立出版 46, 821-828.
  54. Kondo, T. (2001). Reversion of oligodendrocyte precursor cells to multipotent neural stem cells. Biotech Medicine, 20, 4-6.
  55. Raff, M., Apperly, J., Kondo, T., Tokumoto, Y., and Tang, D. (2001). Timing cell-cycle exit and differentiation in oligodendrocyte development. Novartis Found Symp., 237, 00-107.
  56. 近藤　亨 (2001). ラットオリゴデンドロサイト前駆細胞の単離法。実験医学、羊土社 19, 2425-2430.
  57. 近藤　亨 (2000). 神経発生の逆行；オリゴデンドロサイト前駆細胞から神経幹細胞へ。実験医学、羊土社 18, 2684-2686.
  58. 近藤　亨 (1998). 肝炎発症におけるFas/Fasリガンドの働き。免疫 Immunology Frontier、メディカルビュー社 8, 30-33.
  59. 近藤　亨 (1995). Fasリガンド; Fas Ligand.　免疫 Immunology Frontier、メディカルビュー社 5, 39-42.
  60. Mahito Nakanishi, Ken-ichi Ashihara, Takao Senda, Toru Kondo, Keiko Kato, and Tadanori Mayumi. (1995). Gene Introduction into animal tissues. in “Trends and Future perspectives peptide and protein drug delivery” edited by V.H.L., Lee. 337-349. Harwood Academic Publishers Gmbh. Amsterdam, The Netherlands.
  61. 中西真人、芦原賢一、真弓忠範、近藤　亨、米田悦啓 (1995). 生物薬科学実験講座 第３巻、HVJエンベロープタンパク質を用いた細胞内導入法。広川書店
  62. 中西真人、芦原賢一、千田隆夫、近藤　亨、真弓忠範 (1994). 膜融合リポソームを使った細胞への高能率遺伝子導入。実験医学、羊土社 12, 40-44.
  63. 中西真人、近藤　亨、芦原賢一 (1992). 標的臓器への遺伝子導入による治療。 nanoGIGA Vol.1 No.2、日本臨床社 1, 150-154.
  64. 中西真人、加藤啓子、近藤　亨 (1990). 動物個体臓器への遺伝子導入。 代謝別冊、 中山書店 27, 361-365.
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北海道大学　遺伝子病制御研究所　幹細胞生物学分野