Publications | Murakami Lab

2024

191.: Ryutaro Furukawa, Masaki Kuwatani, Jing-Jing Jiang, Yuki Tanaka, Rie Hasebe, Kaoru Murakami, Kumiko Tanaka, Izuru Ohki, Ikuko Takahashi, Takeshi Yamasaki, Yuta Shinohara, Shunichiro Nozawa, Shintaro Hojyo, Shimpei I Kubota, Shigeru Hashimoto, Satoshi Hirano, Naoya Sakamoto, Masaaki Murakami, GGT1 is a SNP eQTL gene involved in STAT3 activation and associated with the development of Post-ERCP pancreatitis, Scientific Reports, in press
190.: Yuki Tanaka, Izuru Ohki, Kaoru Murakami, Satoshi Ozawa, Yaze Wang, Masaaki Murakami, The Gateway Reflex Regulates Tissue-Specific Autoimmune Diseases, Inflammation and Regeneration, in press
189.: Seiichiro Naito, Hiroki Tanaka, Jing-Jing Jiang Masato Tarumi, Ari Hashimoto, Yuki Tanaka, Kaoru Murakami, Shimpei I. Kubota, Shintaro Hojyo, Shigeru Hashimoto, Masaaki Murakami, DDX6 is involved in the pathogenesis of inflammatory diseases via NF-κB activation, Biochemical and Biophysical Research Communications, in press

2023

188.: Hiroki Tanaka, Rie Hasebe, Kaoru Murakami, Toshiki Sugawara, Takeshi Yamasaki, Masaaki Murakami, Gateway Reflexes describe novel neuro-immune communications that establish immune cell gateways at specific vessels, Bioelectronic Medicine, 08 November 2023,9, Article number: 24 (2023) , Article
187.: Kaoru Murakami, Shimpei Kubota, Kumiko Tanaka, Hiroki Tanaka, Keiichiroh Akabane, Rigel Suzuki, Yuta Shinohara, Hiroyasu Takei, Shigeru Hashimoto, Yuki Tanaka, Shintaro Hojyo, Osamu Sakamoto, Norihiko Naono, Takayui Takaai, Kazuki Sato, Yuichi Kojima, Toshiyuki Harada, Takeshi Hattori, Satoshi Fuke, Isao Yokota, Satoshi Konno, Takashi Washio, Takasuke Fukuhara, Takanori Teshima, Masateru Taniguchi, and Masaaki Murakami, High-Precision Rapid Testing of Omicron SARS-CoV-2 Variants in Clinical Samples Using AI-Nanopore, Lab on a Chip, 2023 October 25, Article
186.: Hideaki Shiraishi, Kiyoshi Egawa, Kaoru Murakami, Yuki Ueda, Midori Nakajima, Sachiko Nakakubo, Masashi Narugami, Shuhei Kimura, Takeru Goto, Yasuyoshi Hiramatsu, and Masaaki Murakami, Transcutaneous Auricular Vagus Nerve Stimulation Therapy in Patients with Cognitively Preserved Structural Focal Epilepsy, Brain and Development, 2023 August, (Article)
185.: Yong Bin Teoh, Jing-Jing Jiang, Takeshi Yamasaki, Noriyuki Nagata, Toshiki Sugawara, Rie Hasebe, Hiroshi Ohta, Noboru Sasaki, Nozomu Yokoyama, Kensuke Nakamura, Yumiko Kagawa, Mitsuyoshi Takiguchi, and Masaaki Murakami, An inflammatory bowel disease-associated SNP increases local thyroglobulin expression to develop inflammation in Miniature Dachshunds, Frontiers in Veterinary Science, 14 July 2023, (Article)
184.: Keiichiroh Akabane, Kaoru Murakami, Masaaki Murakami, Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation, Expert Opinion on Therapeutic Targets, 2023 June 20, (Article)
183.: Reiji Yamamoto, Satoshi Yamada, Toru Atsumi, Kaoru Murakami, Ari Hashimoto, Seiichiro Naito, Yuki Tanaka, Izuru Ohki, Yuta Shinohara, Norimasa Iwasaki, Akihiko Yoshimura, Jing-Jing Jiang, Daisuke Kamimura, Shintaro Hojyo, Shimpei I. Kubota, Shigeru Hashimoto, and Masaaki Murakami, Computer simulation of an IL-6 dependent rheumatoid arthritis model in F759 mice, Int Immunol., 2023 May 25, (Article)
182.: Shiina Matsuyama, Reiji Yamamoto, Kaoru Murakami, Nobuhiko Takahashi, Rieko Nishi, Asuka Ishii, Junko Kobayashi, Nobuya Abe, Kumiko Tanaka, Jing-Jing Jiang, Tadafumi Kawamoto, Toshihiko Iwanaga, Yuta Shinohara, Takeshi Yamasaki, Izuru Ohki, Shintaro Hojyo, Rie Hasebe, Shimpei Kubota, Noriyuki Hirata, Daisuke Kamimura, Shigeru Hashimoto, Yuki Tanaka, and, Masaaki Murakami, GM-CSF promotes the survival of peripheral-derived myeloid cells in the CNS for pain-induced relapse of neuroinflammation, Journal of Immunology, 1 July 2023, 1;211(1):34-42.,(Article)
181.: Hajime Senjo, Shinpei Harada, Shimpei Kubota, Yuki Tanaka, Takahiro Tateno, Zixuan Zhang, Satomi Okada, Xuanzhong Chen, Ryo Kikuchi, Naoki Miyashita, Masahiro Onozawa, Hideki Goto, Tomoyuki Endo, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Masaaki Murakami, Takanori Teshima, and Daigo Hashimoto, Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT, Blood, 3 Aug 2023,142(5):477-492.,(Article)
180.: Hiroaki Kida, Jing-Jing Jiang, Yuichiro Matsui, Ikuko Takahashi, Rie Hasebe, Makoto Kondoh, Yasuhiko Nishio, Kinya Nishida, Yoshihiro Matsuno, Tsukasa Oikawa, Shimpei Kubota, Shintaro Hojyo, Norimasa Iwasaki, Shigeru Hashimoto, Yuki Tanaka, and Masaaki Murakami, Dupuytren’s contracture-associated SNPs increase SFRP4 expression in nonimmune cells including fibroblasts to enhance inflammation development, Int Immunol., 31 January 2023, doi:10.1093/intimm/dxad004, (Article)
179.: Takeshi Yamasaki, Noriyuki Nagata, Toru Atsumi, Rie Hasebe, Yuki Tanaka, Izuru Ohki, Shimpei Kubota, Yuta Shinohara, Yong Bin Teoh, Nozomu Yokoyama, Noboru Sasaki, Kensuke Nakamura, Hiroshi Ohta, Takehiko Katsurada, Yoshihiro Matsuno, Shintaro Hojyo, Shigeru Hashimoto, Mitsuyoshi Takiguchi, Masaaki Murakami, Zoobiquity experiments show the importance of the local MMP9-plasminogen axis in inflammatory bowel diseases in both dogs and patients, Int Immunol. 2023 Mar 18, doi: 10.1093/intimm/dxad006. (Article)
178.: Fayrouz Naim, Rie Hasebe, Shintaro Hojyo, Yukatsu Shichibu, Asuka Ishii, Yuki Tanaka, Kazuki Tainaka, Shimpei I. Kubota, Katsuaki Konishi and Masaaki Murakami, In situ Microinflammation Detection Using Gold Nanoclusters and a Tissue-clearing Method, bio-protocol, Vol 13, Iss 7, Apr 5, 2023 DOI: 10.21769/BioProtoc.4644, (Article)
177.: Tianyue Zhai, Takashi Mitamura, Lei Wang, Shimpei I Kubota, Masaaki Murakami, Shinya Tanaka, Hidemichi Watari, Combination therapy with bevacizumab and CCR2 inhibitor for women with ovarian cancer: in vivo validation study, Cancer Medicine, 22 February 2023, doi:10.1002/cam4.5674, (Article)

2022

176.: Takeshi Inoue, Ryo Shinnakasu, Chie Kawai, Hiromi Yamamoto, Shuhei Sakakibara, Chikako Ono, Yumi Itoh, Tommy Terooatea, Kazuo Yamashita, Toru Okamoto, Noritaka Hashii, Akiko Ishii-Watabe, Noah Butler, Yoshiharu Matsuura, Hisatake Matsumoto, Shinya Otsuka, Kei Hiraoka, Takanori Teshima, Masaaki Murakami, and Tomohiro Kurosaki, Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees, Journal of Experimental Medicine, 13 December 2022, doi:10.1084/jem.20221786, (Article)
175.: Nobuya Abe, Michihiro Kono, Michihito Kono , Takayuki Katsuyama, Kazumasa Ohmura, Taiki Sato, Kohei Karino, Yuichiro Fujieda, Masaru Kato, Rie Hasebe, Masaaki Murakami, Tatsuya Atsumi, Cytokine and chemokine multiplex analysis-based exploration for potential treatment and prognostic prediction in large-vessel vasculitis: a preliminary observational study, Frontiers in Immunology, doi:10.3389/fimmu.2022.1066916, (Article)
174.: Kaoru Murakami, Sumio Iwasaki, Satoshi Oguri, Kumiko Tanaka, Rigel Suzuki, Kasumi Hayasaka, Shinichi Fujisawa, Chiaki Watanabe, Satoshi Konno, Isao Yokota, Takasuke Fukuhara, Masaaki Murakami, Takanori Teshimach, SARS-CoV-2 Omicron detection by antigen tests using saliva, Journal of Clinical Virology Plus, doi:10.1016/j.jcvp.2022.100109, (Article)
173.: Nobuya Abe, Masato Tarumi, Yuichiro Fujieda, Nobuhiko Takahashi, Kohei Karino, Mona Uchida, Michihito Kono, Yuki Tanaka, Rie Hasebe, Masaru Kato, Olga Amengual, Yoshiyuki Arinuma, Kenji Oku, Wakiro Sato, Khin Khin Tha, Miwako Yamasaki, Masahiko Watanabe, Tatsuya Atsumi, Masaaki Murakami, Pathogenic neuropsychiatric effect of stress-induced microglial interleukin 12/23 axis in systemic lupus erythematosus, Ann. Rheum. Dis., doi:10.1136/ard-2022-222566, (Article) (PDF)
172.: Nobuya Abe, Michihito Kono, Michihiro Kono, Naoki Ohnishi, Tomoya Sato, Masato Tarumi, Masaru Yoshimura, Taiki Sato, Kohei Karino, Yuka Shimizu, Yuichiro Fujieda, Masaru Kato, Rie Hasebe, Kenji Oku, Masaaki Murakami, Tatsuya Atsumi. Glycogen synthase kinase 3β/CCR6-positive bone marrow cells correlate with disease activity in multicentric Castleman disease-TAFRO, British Journal of Haematology. 2022. 196(5):1194-1204.
171.: Takashi Kudo, Daigo Nakazawa, Kanako Watanabe-Kusunoki, Masatoshi Kanda, Satoka Shiratori-Aso, Nobuya Abe, Saori Nishio, Jun-Ichiro Koga, Sari Iwasaki, Takahiro Tsuji, Yuichiro Fukasawa, Miwako Yamasaki, Masahiko Watanabe, Sakiko Masuda, Utano Tomaru, Masaaki Murakami, Yasuaki Aratani, Akihiro Ishizu, Tatsuya Atsumi, Regulation of NETosis and Inflammation by Cyclophilin D in Myeloperoxidase-Positive Antineutrophil Cytoplasmic Antibody–Associated Vasculitis, Arthritis & Rheumatology, 29 July 2022, doi: 10.1002/art.42314(Article)
170.: Rie Hasebe, Kaoru Murakami, Masaya Harada, Nada Halaka, Hiroshi Nakagawa, Fuminori Kawano, Yoshinobu Ohira, Tadafumi Kawamoto, Fiona E. Yull, Timothy S. Blackwell, Junko Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, Nobuhiro Watanabe, Harumi Hotta, Toshihide Yamashita, Daisuke Kamimura, Yuki Tanaka, Masaaki Murakam, ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons. J. Exp. Med. May 2022, 219(6), doi: 10.1084/jem.20212019 (Article)
169.: Kevin J Tracey, Sangeeta Chavan, Masaaki Murakami, Introduction: Electronic Medicine in Immunology Special Issue Part 2, Int. Immunol., 29 July 2022, doi: 10.1093/intimm/dxab100 (Article)

2021

168.: Kaoru Murakami, Yuki Tanaka, Masaaki Murakami, The gateway reflex: breaking through the blood barriers, Int. Immunol., Volume 33, Issue 12, doi:10.1093/intimm/dxab064, (Article)
167.: Kevin J Tracey, Sangeeta Chavan, Masaaki Murakami, Introduction: Electronic Medicine in Immunology Special Issue Part 1, Int. Immunol., 33(6), 299-300, June 2021, doi: 10.1093/intimm/dxab024 (Article)
166.: Shiina Matsuyama, Yuki Tanaka, Rie Hasebe, Shintaro Hojyo and Masaaki Murakami, Gateway Reflex and Mechanotransduction, Front. Immunol., 22 December 2021, doi: 10.3389/fimmu.2021.780451. (Article)
165.: Andrea Stofkova, Miloslav Zloh, Dominika Andreanska, Ivana Fiserova, Jan Kubovciak, Jan Hejda, Patrik Kutilek and Masaaki Murakami, Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex, Int. J. Mol. Sci., 2022, 23(1), 453; doi: 10.3390/ijms23010453. (Article)
164.: Emoto S, Shibasaki S, Nagatsu A, Goto R, Ono H, Fukasaku Y, Igarashi R, Ota T, Fukai M, Shimamura T, Saiga K, Taketomi A, Murakami M, Todo S, Yamashita K. Triazolopyrimidine derivative NK026680 and donor-specific transfusion induces CD4(+)CD25(+)Foxp3(+) T cells and ameliorates allograft rejection in an antigen-specific manner. Transpl Immunol. 65:101338 (2021) doi: 10.1016/j.trim.2020.101338. (PubMed)
163.: Shimoyama S, Nakagawa I, Jiang J-J, Matsumoto I, Chiorini JA, Hasegawa Y, Ohara O, Hasebe R, Ota M, Uchida M, Kamimura D, Hojyo S, Tanaka Y, Atsumi T, Murakami M. Sjögren’s syndrome-associated SNPs increase GTF2I expression in salivary gland cells to enhance inflammation development. Int Immunol. 2021 May 24, doi: 10.1093/intimm/dxab025.(PubMed)
162.: Uchida M, Yamamoto R, Matsuyama S, Murakami K, Hasebe R, Hojyo S, Tanaka Y, Murakami M. Gateway reflexes, neuronal circuits that regulate the gateways for autoreactive T cells in organs that have blood barriers. Int Immunol. 2021 May 12, doi: 10.1093/intimm/dxab022. (PubMed)
161.: Murakami K, Kamimura D, Hasebe R, Uchida M, Abe N, Yamamoto R, Jiang J-J, Hidaka Y, Nakanishi Y, Fujii S, Toda Y, Toda N, Tanaka H, Akira S, Tanaka Y, Murakami M. Rhodobacter azotoformans BP0899 LPS（RAP99-LPS） is a TLR4 agonist that inhibits lung metastasis and enhances TLR3-mediated chemokine expression. Front Immunol. 25 May 2021, doi: 10.3389/fimmu.2021.675909

2020

160.: Hojyo, S., Uchida M., Tanaka K., Hasebe R., Tanaka Y., Murakami M., Hirano T., How COVID-19 induces cytokine storm with high mortality, Inflamm Regen. 40:37, 2020.10, doi: 10.1186/s41232-020-00146-3(PubMed)
159.: Takada Y., Kamimura D., J-J. Jiang., Higuchi H., Iwami D., Hotta K., Tanaka Y., Ota M., Higuchi M., Nishio S., Atsumi T., Shinohara N., Matsuno Y., Tsuji T., Tanabe T., Sasaki H., Iwahara N., and Murakami M. Increased urinary exosomal SYT17 in chronic active antibodymediated rejection after kidney transplantation via the IL-6 amplifier. Int Immunol. 32(10): 653-662, 2020, doi: 10.1093/intimm/dxaa032.(PubMed)
158.: Hirano, T., M. Murakami. COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome. Immunity 2020 52:1-3 DOI: 10.1016/j.immuni.2020.04.003(PubMed)
157.: Higuchi, H., D. Kamimura, J-J. Jiang, T. Atsumi, D. Iwami, K. Hotta, H. Harada, Y. Takada, H. Kanno-Okada, KC. Hatanaka, Y. Tanaka, N. Shinohara, and M. Murakami. Orosomucoid 1 is involved in the development of chronic allograft rejection after kidney transplantation. Int Immunol. 32(5):335-346, 2020, doi: 10.1093/intimm/dxaa024.(PubMed)
156.: Kamimura, D., Y. Tanaka, R. Hasebe and M. Murakami. Bidirectional communication between neural and immune systems. Int Immunol. 2020 Oct 20;32(11):693-701. doi: 10.1093/intimm/dxz083. (Review)(PubMed)
155.: Ota, M., Tanaka Y., Nakagawa I., Jiang J-J., Arima Y., Kamimura D., Onodera T., Iwasaki N., and Murakami M. Chondrocytes play a role in the development of rheumatoid arthritis via TMEM147-mediated NF-κB activation. Arthritis Rheumatol. 72(6):931-942, 2020, doi: 10.1002/art.41182(PubMed)

2019

154.: Hashimoto, S., S. Furukawa, A. Hashimoto, A. Tsutaho, A. Fukao, Y. Sakamura, G. Parajuli, Y. Onodera, Y. Otsuka, H. Handa, T. Oikawa, S. Hata, Y. Nishikawa, Y. Mizukami, Y. Kodama, M. Murakami, T. Fujiwara, S. Hirano, and H. Sabe. ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer. PNAS 2019 Aug 9. pii: 201901765. doi: 10.1073/pnas.1901765116. (PubMed)
153.: Stofkova, A., and M. Murakami. Neural activity regulates autoimmune diseases through the gateway reflex. Bioelectric Med. 5, Article number: 14, 2019 (Bioelect Med.) (Review)
152.: Nishida, K., A. Hasegawa A, S. Yamasaki, R. Uchida, W. Ohashi, Y. Kurashima, J. Kunisawa, S. Kimura, T. Iwanaga, H. Watarai, K. Hase, H. Ogura, M. Nakayama, JI Kashiwakura, Y. Okayama, M. Kubo, O. Ohara, H. Kiyono, H. Koseki, M. Murakami, and T. Hirano. Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis. Sci Rep. 2019 Jul 25;9(1):10842. doi: 10.1038/s41598-019-47132-5. (PubMed)
151.: Tanaka, H., Y. Arima, D. Kamimura, Y. Tanaka, N. Takahashi, T. Uehata, K. Maeda, T. Satoh, M. Murakami, and S. Akira. Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response. J Exp Med. Jun 3;216(6):1431-1449. doi: 10.1084/jem.20181078.（PubMed)
150.: Murakami, M., D. Kamimura and T. Hirano. Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines. Immunity. 50(4), 812-831, 2019. doi: 10.1016/j.immuni.2019.03.027. (PubMed) (Review)
149.: Kamimura, D., and M. Murakami. Neural stimulations regulate the infiltration of immune cells into the CNS. J Intern Med. Sep;286(3):259-267. doi: 10.1111/joim.12912, 2019 (PubMed) (Review)
148.: Stofkova, A., D. Kamimura, T. Ohki, M. Ota, Y. Arima, and M. Murakami. Photopic light-mediated down-regulation of local α1A-adrenergic signaling protects blood-retina barrier in experimental autoimmune uveoretinitis. Sci Rep. 9, Article number: 2353, 2019. (PubMed)
147.: Fujita, M., Y. Yamamoto, J-J. Jiang, T. Atsumi, Y. Tanaka, T. Ohki, N. Murao, E. Funayama, T. Hayashi, M. Osawa, T. Maeda, D. Kamimura, and M. Murakami. NEDD4 is involved in inflammation development during keloid formation. J Invest Dermatol. 139, 333-341, 2019. (PubMed) (Commentary in JID)
146.: Kamimura, D., T. Ohki, Y. Arima, M. Ota and M. Murakami. Gateway reflex: Local neuroimmune interactions that regulate blood vessels. Neurochem Int. 130, 104303, 2019. (PubMed) (Review)

2018

145.: Tanaka, Y.*, L. Sabharwal* (Equal contribution), M. Ota, I. Nakagawa, J-J. Jiang, Y. Arima, H. Ogura, M. Okochi, 　M. Ishii, D. Kamimura# and M. Murakami# (#Corresponding authors). Presenilin 1 regulates NF-κB activation via association with breakpoint cluster region and casein kinase II. J Immunol. Oct 15;201(8):2256-2263, 2018. doi: 10.4049/jimmunol.1701446. (PubMed)
144.: Okuyama, Y.*, Y. Tanaka*, J-J. Jiang*, D. Kamimura*# (*Equal contribution, #Corresponding authors), A. Nakamura, M. Ota, T. Ohki, D. Higo, H. Ogura, N. Ishii, T. Atsumi and M. Murakami#. Bmi1 regulates IkBa degradation via association with the SCF complex. J Immunol. Oct 15;201(8):2264-2272, 2018. doi: 10.4049/jimmunol.1701223. (PubMed)
143.: Kamimura, D., T. Ohki, Y. Arima, and M. Murakami. Gateway reflex: neural activation-mediated immune cell gateways in the central nervous system. Int Immunol. 30(7), 281-289, 2018 May 15. doi: 10.1093/intimm/dxy034. (PubMed) (Review)
142.: Tainaka, K., TC. Murakami, EA. Susaki, C. Shimizu, R. Saito, K. Takahash, A. Hayashi-Takagi, H. Sekiya, Y. Arima, S. Nojima, M. Ikemura, T. Ushiku, Y. Shimizu, M. Murakami, KF. Tanaka, M. Iino, H. Kasai, T. Sasaoka, K. Kobayashi, K. Miyazono, E. Morii, T. Isa, M. Fukayama, A. Kakita, and HR. Ueda. Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents. Cell Rep. 2018 Aug 21;24(8):2196-2210.e9. doi: 10.1016/j.celrep.2018.07.056. (PubMed)
141.: Itabashi, T., Y. Arima, D. Kamimura, K. Higuchi, Y. Bando, H. Takahashi-Iwanaga, M. Murakami, M. Watanabe, and T. Iwanaga. Cell- and stage-specific localization of galectin-3, a beta-galactoside-binding lectin, in a mouse model of experimental autoimmune encephalomyelitis. Neurochem Int. 118: 176-184, 2018. doi: 10.1016/j.neuint.2018.06.007. (PubMed)
140.: Kijimoto-Ochiai, S., T. M-Mizuno, D. Kamimura, M. Murakami, M. Kobayashi, I Matsuoka, H. Ochiai, H. Ishida, M. Kiso, K. Kamimura, and T. Koda. Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5. Glycobiology 28(5): 306-317, 2018 doi: 10.1093/glycob/cwy009 (Glycobiology)

2017

139.: Atsumi, T.*, H. Suzuki*, J-J. Jiang* (* equal contribution), Y. Okuyama, I. Nakagawa, M. Ota, Y. Tanaka, T. Ohki, K. Katsunuma, K. Nakajima, Y. Hasegawa, O. Ohara, H. Ogura, Y. Arima, D. Kamimura, and M. Murakami. Rbm10 regulates inflammation development via alternative splicing of Dnmt3b. Int Immunol. 29(12):581-591, 2017. doi: 10.1093/intimm/dxx067. (PubMed)
138.: Tanaka, T., Y. Arima, D. Kamimura, and M. Murakami. The gateway reflex, a novel neuro-immune interaction for the regulation of regional vessels. Front Immunol. Oct 18;8:1321, doi: 10.3389/fimmu.2017.01321. 2017. (PubMed)
137.: Arima, Y.*, T. Ohki*, N. Nishikawa*, K. Higuchi* (* equal contribution), M. Ota, Y. Tanaka, J. Nio-Kobayashi, M. Elfeky, R. Sakai, Y. Mori, T. Kawamoto, A. Stofkova, Y. Sakashita, Y. Morimoto, M. Kuwatani, T. Iwanaga, Y. Yoshioka, N. Sakamoto, A. Yoshimura, M. Takiguchi, S. Sakoda, M. Prinz, D. Kamimura, M. Murakami. Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit. eLife 6:e25517 DOI: 10.7554/eLife.25517, 2017 (eLife)
136.: Elfeky, M., D. Kamimura, Y. Arima, M. Murakami and L. Steinman. Targeting molecules involved in immune cell trafficking to the central nervous system for therapy in multiple sclerosis. Clin Exp Neuroimmunol. 8(3), 183-191, 2017 (CENI) (Review)
135.: Tanaka, Y., Y. Arima, K. Higuchi, T. Ohki, M. Elfeky, M. Ota, D. Kamimura and M. Murakami. EAE Induction by Passive Transfer of MOG-specific CD4+ T Cells. Bio-protocol. 7(13), 7/5/2017, DOI: https://doi.org/10.21769/BioProtoc.2370, 2017 (Bio-Protocol)
134.: Kitada, S. H. Kayama, D. Okuzaki, R. Koga, M. Kobayashi, Y. Arima, A. Kumanogoh, M. Murakami, M. Ikawa, K. Takeda. BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. J. Exp. Med. 214(5):1313-1331, 2017 (PubMed)
133.: Murakami, M. Recent advances in neuroimmune interactions. Clin Exp Neuroimmunol. 8: 3-4, 2017 (CEN) (Editorial)
132.: Ohki, T., D. Kamimura, Y. Arima, M. Murakami. Gateway reflex, a new paradigm of neuro-immune interaction. Clin Exp Neuroimmunol. 8: 23-32, 2017 (CEN) (Review)
131.: Higuchi, K., D. Kamimura, A. Stofkova, N. Nishikawa, T. Ohki, Y. Arima, M. Murakami. Gateway reflexes are stimulated by neural activations and promote the pathogenesis of multiple sclerosis models. Nutrition and Lifestyle in Neurological Autoimmune Diseases. Chapter 5, 39-45, 2017 (Elsevier) (Review)

2016

130.: Meng, J.*, J-J Jiang* (*Equal contribution), T. Atsumi, H. Bando, Y. Okuyama, L. Sabharwal, I. Nakagawa, H. Higuchi, M. Ota, M. Okawara, R. Ishitani, O. Nureki, D. Higo, Y. Arima, H. Ogura, D. Kamimura and M. Murakami. Breakpoint cluster region-mediated inflammation is dependent on casein kinase II. J Immunol 197(8), 3111-3119, 2016 (PubMed)
129.: Ota, M., D. Kamimura, I. Nakagawa, H. Higuchi, Y. Tanaka, M. Fujita, S. Hiratsuka, M. Okawara, K. Murakami, T. Atsumi, Y. Arima and M. Murakami. Control of chronic inflammation by the inflammation amplifier and gateway reflexes. Advances in Medicine and Biology 104: Chapter 4, 65-86, 2016 (Review) (NOVA)
128.: Kamimura, D. Y. Arima, M. Tsuruoka, J-J Jiang, H. Bando, J. Meng, L. Sabharwal, A. Stofkova, N. Nishikawa, K. Higuchi, H. Ogura, T. Atsumi, M. Murakami. Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naïve T cells. Int Immunol. 28(3), 117-126, 2016. doi: 10.1093/intimm/dxv059 (PubMed) (Featured article in Int Immunol)

2015

127.: Nakagawa, I., D. Kamimura, T. Atsumi, Y. Arima, M. Murakami. Role of inflammation amplifier-induced growth factor expression in the development of inflammatory diseases. Crit Rev Immunol. 35(5), 365-78, 2015 (Review)
126.: Kamimura, D., T. Atsumi, A. Stofkova, N. Nishikawa, T. Ohki, H. Suzuki, K. Katsunuma, J-J Jiang, H. Bando, J. Meng, L. Sabharwal, H. Ogura, T. Hirano, Y. Arima, M. Murakami. Naive T cell homeostasis regulated by stress responses and TCR signaling. Front Immunol 6, Article 638, 2015 doi: 10.3389/fimmu.2015.00638 (Review)
125.: Nakanishi, K., M. Nishida1, M. Harada, T. Ohama, N. Kawada, M. Murakami, T. Moriyama1, K. Yamauchi-Takihara. Klotho-related molecules upregulated by smoking habit in apparently healthy men: A crosssectional study. Sci Rep. 5: 14230, 2015 (Sci Rep)
124.: Arima, Y., K. Higuchi, N. Nishikawa, A. Stofkova, T Ohki, D. Kamimura, M. Murakami. Pain is an inducer for relapse in multiple sclerosis models via a regional neural signal. Clin Exp Neuroimmunol. 6, 343-344, 2015 DOI: 10.1111/cen3.12250 (Review) (CEN)
123.: Kamimura, D., Y. Arima, T. Atsumi, J. Meng, L. Sabharwal, H. Bando, J-J. Jiang, ES. Huseby, M. Murakami. Role of cytokine-mediated crosstalk between T cells and nonimmune cells in the pathophysiology of multiple sclerosis. Chapter 6 in Multiple Sclerosis (Elsevier) 2015. (Review)
122.: Arima, Y*., D. Kamimura* (*Equal contribution), T. Atsumi, M. Harada, T. Kawamoto, N. Nishikawa, A. Stofkova1, T. Ohki, K. Higuchi, Y. Morimoto, P. Wieghofer, Y. Okada, Y. Mori, S. Sakoda, S. Saika, Y. Yoshioka, I. Komuro, T. Yamashita, T. Hirano, M. Prinz, M. Murakami. A pain-mediated neural signal induces relapse in multiple sclerosis models. eLife 4: e08733, 2015 doi: 10.7554/eLife.08733. (eLife)
121.: Huseby, ES., D. Kamimura, Y. Arima, CS. Parello, K. Sasaki, M. Murakami. Role of T cell – glial cell interactions in creating and amplifying Central Nervous System inflammation and Multiple Sclerosis disease symptoms. Frontiers in Cellular Neuroscience. 9, Article 295, 2015 doi: 10.3389/fncel.2015.00295. (Review) (PubMed)
120.: Ito, D., S. Nojima, M. Nishide, T. Okuno, H. Takamatsu, S. Kang, T. Kimura, Y. Yoshida, K. Morimoto, Y. Maeda, T. Hosokawa, T. Toyofuku, J. Ohshima, D. Kamimura, M. Yamamoto, M. Murakami, E. Morii, H. Rakugi, Y. Isaka, A. Kumanogoh. mTOR complex signaling through the SEMA4A-Plexin B2 axis is required for optimal activation and differentiation of CD8+ T cells. J Immunol. 195(3):934-43, 2015 (PubMed)
119.: Hashimoto-Kataoka, T., N. Hosen, T. Sonobe, Y. Arita, T. Yasui, T. Masaki, M. Minami, T. Inagaki, S. Miyagawa, Y. Sawa, M. Murakami, A. Kumanogoh, K. Yamauchi-Takihara, M. Okumura, T. Kishimoto, I. Komuro, M. Shirai, Y. Sakata, Y. Nakaoka. Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension. Proc Natl Acad Sci USA. 2015 May 19;112(20):E2677-86. (PubMed)
118.: Kamimura, D.*#, K. Katsunuma*, Y. Arima, T. Atsumi, J-J Jiang, H. Bando, J. Meng, L. Sabharwal, A. Stofkova, N. Nishikawa, H. Suzuki, H. Ogura, N. Ueda, M. Tsuruoka, M. Harada, J. Kobayashi, T. Hasegawa, H. Yoshida, H. Koseki, I. Miura, S. Wakana, K. Nishida, H. Kitamura, T. Fukada, T. Hirano, and M. Murakami#. (*Equal contribution, #Equal correspondence), KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR. Nat. Commun. 6, Article number: 7474, doi:10.1038/ncomms8474, 2015 (Nat Commun.)
117.: Maeda, K., T. Kosugi, W. Sato, H. Kojima, Y. Sato, D. Kamimura, N. Kato, N. Tsuboi, Y. Yuzawa, S. Matsuo, M. Murakami, S. Maruyama, K. Kadomatsu. CD147/Basigin limits lupus nephritis and TH17 cell differentiation by inhibiting the IL-6/STAT3 pathway. Arthritis Rheumatol. 6(2):120–128, 2015. (A&R)
116.: Kamimura, D., A. Stofkova, N. Nishikawa, T. Atsumi, Y. Arima, M. Murakami. Immune Cell Gateways in the CNS Regulated by Regional Neural Stimulations. Clin Exp Neuroimmunol. 6(2):120–128, 2015. DOI: 10.1111/cen3.12198 (Review) (CEN)
115.: Harada, M.*, D. Kamimura* (*, equal contribution),Y. Arima, H. Kohsaka, Y. Nakatsuji, M. Nishida, T. Atsumi, J. Meng, H. Bando, Sngh, L. Sabharwal, J-J. Jiang, N. Kumai, N. Miyasaka, S. Sakoda, K. Yamauchi-Takihara, H. Ogura, T. Hirano and M. Murakami. Temporal Expression of Growth Factors Triggered by Epiregulin Regulates Inflammation Development. J. Immunol. 194(3):1039-46, 2015 (PubMed)

2014

114.: Sabharwal, L.*, D. Kamimura* (*, equal contribution), J. Meng, H. Bando, H. Ogura, C. Nakayama, J-J. Jiang, N. Kumai, H. Suzuki, T. Atsumi, Y. Arima and M. Murakami. The Gateway Reflex, which is mediated by the inflammation amplifier, directs pathogenic immune cells into the CNS. J. Biochem. 156(6):299-304, 2014 (PubMed) (Review)
113.: Hojyo S., T. Miyai, H. Fujishiro, M. Kawamura, T. Yasuda, A. Hijikata, B-H Bin, T. Irié, J. Tanaka, T. Atsumi, M. Murakami, M. Nakayama, O. Ohara, S. Himeno, H. Yoshida, H. Koseki, T. Ikawa, K. Mishima, and T. Fukada. Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. Proc Natl Acad Sci USA 12;111(32):11786-91, 2014 (PubMed)
112.: Atsumi, T., R. Singh, L. Sabharwal, H. Bando, J. Meng, Y. Arima, M. Yamada, M. Harada, J-J Jiang, D. Kamimura, H. Ogura, T. Hirano, and M. Murakami. Inflammation amplifier, a new paradigm in cancer biology. Cancer Research 74(1): 8-14, 2014 (PubMed) (Review)
111.: Ogura, H., T. Atsumi, H. Bando, L. Sabharwal, M. Yamada, J.-J. Jiang, A. Nakamura, Y. Arima, D. Kamimura, and M. Murakami. The reverse-direction method links mass experimental data to human diseases. Archivum Immunologiae et Therapiae Experimentalis 62(1): 41-45, 2014 (PubMed) (Review)
110.: Mori, Y*, M. Murakami#,*, Y. Arima*, D. Zhu, Y. Terayama, Y. Komai, Y. Nakatsuji, D. Kamimura, and Y. Yoshioka (*, equal contribution; #, correspondence) Early pathological alterations of lower lumber cords detected by ultra-high field MRI in a mouse multiple sclerosis model. Int Immunol. 26(2): 93-101, 2014 (PubMed)

2013

109.: Kamimura, D., M Yamada, M Harada, L. Sabharwal, J Meng, H Bando, H Ogura, T Atsumi, Y Arima, M Murakami. The gateway theory: bridging neural and immune interactions in the CNS. Front. Neurosci. doi: 10.3389/fnins.2013.00204 (PubMed)(Review)
108.: Singh, R., T Atsumi, H Bando, M Harada, A Nakamura, M Yamada, J-J Jiang, H Suzuki, K Katsunuma, T Nodomi, D Kamimura, H Ogura, M Murakami. Reverse direction method: A possible tool to link animal models with corresponding human diseases and disorders. Int. J. Genomic Med. 1:106. doi: 10.4172/ijgm.1000106, 2013 (Int J Genomic Med) (Review)
107.: Kamimura, D., M Yamada, L Sabharwal, H Ogura, Y Okuyama, A Nakamura, T Atsumi, Y Arima, M Murakami. The Gate Theory Explains Regional Neural Regulation of Activated T cells Entering the Central Nervous System. Journal of Clinical & Cellular Immunology 4:156 doi: 10.4172/2155-9899.1000156. (J Clin Cell Immunol) (Review)
106.: Murakami M*#, M Harada*, D Kamimura*, H Ogura, Y Okuyama, N Kumai, A Okuyama, R Singh, J Jiang, T Atsumi, S Shiraya, Y Nakatsuji, M Kinoshita, H Kohsaka, M Nishida, S Sakoda, N Miyasaka, K Yamauchi-Takihara, T Hirano# (*, equal contribution; #, correspondence) Disease-Association Analysis of an Inflammation-Related Feedback Loop. Cell Reports. 3: 946-959, 2013 (PubMed)
105.: Sasaki M, A Tojo, Y Okochi, N Miyawaki, D Kamimura, A Yamaguchi, M Murakami, Y Okamura. Autoimmune disorder phenotype in HVCN1 gene deficient mice. Biochem. J. 450: 295-301, 2013 (PubMed)
104.: Lee J*, T Nakagiri*, D Kamimura*, M Harada, T Oto, Y Susaki, Y Shintani, M Inoue, S Miyoshi, E Morii, T Hirano, M Murakami#, M Okumura. (*, equal contribution; #, correspondence) IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation. Int Immunol. 25: 319-332, 2013 (PubMed)
103.: Kusu T, H Kayama, M Kinoshita, S Gyu-Jeon, Y Ueda, Y Goto, R Okumura, H Saiga, T Kurakawa, K Ikeda, Y Maeda, J Nishimura, Y Arima, K Atarashi, K Honda, M Murakami, J Kunisawa, H Kiyono, M Okumura, M Yamamoto, K Takeda. Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine. J Immunol. 190: 774-783, 2013 (PubMed)
102.: Arima Y, D. Kamimura, L. Sabharwal, M. Yamada, H. Bando, H. Ogura, T. Atsumi and M Murakami. Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory. Mediators of Inflammation. vol. 2013, Article ID 898165, 8 pages, 2013. doi:10.1155/2013/898165 (Mediators Inflamm.) (Review)
101.: Ogura H, Y. Arima, D. Kamimura, and M Murakami# (#, correspondence) The Gate Theory: How Regional Neural Activation Creates a Gateway for Immune Cells via an Inflammation Amplifier. Biomedical J. 36(6): 269-273, 2013 (PubMed) (Review)

2012

100.: Lee J, T Nakagiri, T Oto, M Harada, E Morii, Y Shintani, M Inoue, Y Iwakura, S Miyoshi, M Okumura, T Hirano, M Murakami#. IL-6 Amplifier, NF-κB-Triggered Positive Feedback for IL-6 Signaling, in Grafts Is Involved in Allogeneic Rejection Responses. (#, correspondence) J Immunol. 189: 1928-1936, 2012 (PubMed) (MDLinks)
99.: Kayama H, Y Ueda, Y Sawa, SG Jeon, JS Ma, R Okumura, A Kubo, M Ishii, T Okazaki, M Murakami, M Yamamoto, H Yagita, K Takeda. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. Proc. Natl. Acad. Sci. USA. 109: 5010-5015, 2012 (PubMed)
98.: Arima Y, M Harada, D Kamimura, J Park, F Kawano, FE Yull, T Kawamoto, Y Iwakura, UAK Betz, G Márquez, T S Blackwell, Y Ohira, T Hirano, M Murakami#. Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier. (#, correspondence) Cell. 148: 447-457, 2012 (PubMed) (Cell Previews) (Research Highlight in Nature Reviews of Neuroscience) (Pain Research Forum) (Global Medical Discovery)
97.: Murakami M#, T Hirano. (#, correspondence) The Molecular Mechanisms of Chronic Inflammation Development Front. Immunol. 07 October 2012 | doi: 10.3389/fimmu.2012.00323 (Front. Immunol.) (Review)
96.: Murakami M#, T Hirano. The pathological and physiological roles of IL-6 amplifier activation. (#, correspondence) Int. J. Biol. Sci. 8: 1267-1280. 2012 (PubMed) (Review)

2011

95.: Verjan Garcia N, E Umemoto, Y Saito , M Yamasaki, E Hata, T Matozaki, M Murakami, YJ Jung, SY Woo, JY Seoh, MH Jang, K Aozasa, M Miyasaka. SIRPalpha/CD172a Regulates Eosinophil Homeostasis. J. Immunol. 187: 2268-2277, 2011 (PubMed)
94.: Murakami M*, Y Okuyama*, H Ogura*, S Asano, Y Arima, M Tsuruoka, M Harada, M Kanamoto, Y Sawa, Y Iwakura, K Takatsu, D Kamimura, T Hirano. (*equal contribution) Local microbleeding facilitates IL-6– and IL-17–dependent arthritis in the absence of tissue antigen recognition by activated T cells. J. Exp. Med. 208: 103-114, 2011 (PubMed) (Research Highlight in Nature Review Immunology)
93.: Nishida K., T Fukada, S Yamasaki, M Murakami, T Hirano. Zinc in Allergy, Autoimmune, and Hard and Connective Tissue Diseases. in Zinc in Human Health edited by L. Rink., IOS Press, 268-282, 2011. (Review)
92.: Fukada, T, K Nishida, S Yamazaki, M Murakami, T Hirano. Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem.16:1123-1134, 2011 (PubMed) (Review)
91.: Murakami M, T Hirano. A four step model for the IL-6 amplifier, a regulator of chromic inflammations in tissue specific MHC class II-associated autoimmune diseases. Front. Immun. 2:22. doi: 10.3389/fimmu.2011.00022 (Front. Immun,) (Review)

2010

90.: Kitabayashi C, T. Fukada M Kanamoto, W Ohashi, S Hojyo, T Atsumi, N Ueda, I Azuma, H Hirota, M Murakami, T Hirano. Zinc suppresses Th17 development via inhibition of STAT3 activation. Int. Immunol. 22: 375-386, 2010 (PubMed) (Editor's choice: featured articles)
89.: Nakagawa T*, M Tsuruoka*, H Ogura, Y Okuyama, Y Arima, T Hirano, M Murakami#. (*equal contribution; #, correspondence) IL-6 positively regulates Foxp3+CD8+ T cells in vivo. Int. Immunol. 22(2):129-139, 2010 (PubMed) (Editor's choice: featured articles)

2009

88.: Sawa Y, Y Arima, H Ogura, C Kitabayashi, J Jiang, T Fukushima, D Kamimura, T Hirano, M Murakami#. (#, correspondence) Hepatic Interleukin-7 Expression Regulates T Cell Responses. Immunity 30: 447-457, 2009 (PubMed) (Immunity Preview) (Comment in Science-Buisiness eXchange)
87.: Atsumi T*, M Sato*, D Kamimura, A Moroi, Y Iwakura, UAK Betz, A Yoshimura, M Nishihara, T Hirano, M Murakami#. (*equal contribution; #, correspondence) IFN-γ expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. Int. Immunol. 21: 73-80, 2009 (PubMed)

2008

86.: Ogura H*, M Murakami*, Y Okuyama, M Tsuruoka, C Kitabayashi, M Kanamoto, M Nishihara, Y Iwakura T Hirano. (*equal contribution) Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction. Immunity, 29: 628-636, 2008. (PubMed)
85.: Jin G, T Hirano, M Murakami#. Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation. (#, correspondence) Int. Immunol. 20: 783-789, 2008. (PubMed)
84.: Tanaka Y, N Tanaka, Y Saeki, K Tanaka, M Murakami, T Hirano, N Ishii, K Sugamura. c-Cbl-dependent Monoubiquitination and Lysosomal Degradation of gp130. Mol. Cell. Biol. 28: 4805-4818, 2008.(PubMed)
83.: Murakami M, Hirano T. Intracellular Zinc homeostasis and Zinc signaling. Cancer Science 99: 1515-22, 2008.(PubMed) (Review)
82.: Hirano T, M Murakami, T Fukada, K Nishida, S Yamasaki, T Suzuki. Roles of Zinc and Zinc signaling in immunity: Zinc is an intracellular signaling molecule. Advances in Immunology. 97: 149-176, 2008. (PubMed)(Review)

2007

81.: *Nishihara M, *H Ogura, N Ueda, M Tsuruoka, C Kitabayashi, F Tuji, H Aono, K Ishihara, E Huseby, UAK Betz, M Murakami, T Hirano. (*equal contribution) IL-6-gp130-STAT3 in T cells directs the development of IL-17+T helper cells with a minimum effect on that of Treg in the steady state. Int. Immunol. 19: 695-702,2007. (PubMed)
80.: *Khiong K, *M Murakami#, C Kitabayashi, N Ueda, S Sawa, A Sakamoto, BL Kotzin, SJ. Rozzo, K Ishihara, M Verella-Garcia, J Kappler, P Marrack, T Hirano. (*equal contribution; #, correspondence). Homeostatic proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J. Clin. Invest. 117: 1270-1281, 2007(PubMed) (Full text of JCI) (Commentary in JCI) (Research Highlights in Nature Immunology) (Research Highlight in Nature Reviews Immunology)

2006

79.: Kamon H, T Kawabe, H Kitamura, D Kamimura, G Jin, T Kaisyo, S Akira, A Iwamatsu, H Koga, K Ishihara, M Murakami, T Hirano. TRIF-GEFH1-RhoB cascade regulates surface expression of MHC class II in dendritic cells that is critical for CD4+ T cell activation. EMBO J. 25: 4108-4119, 2006. Epub 2006 Aug 17 (PubMed)
78.: Ueda N, H Kuki, D Kamimura, S Sawa, K Seino, M Taniguchi, T Hirano, M Murakami#. (#, correspondence) CD1d-restricted natural killer T cell activation enhanced homeostatic proliferation of CD8+T cells in a manner dependent on IL-4. Int. Immunol.18: 1397-1404, 2006. Epub 2006 Aug 16 (PubMed)
77.: Kitamura H, H Morikawa, H Kamon, M Iguchi, S Hojyo, T Fukada, S Yamashita, T Kaisho, S Akira, M Murakami T Hirano. Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat. Immunol.7: 971-977, 2006 (PubMed) (Research Highlights in Nature) (RIKEN RESEARCH) (Spotlight of ACS Chemical Biology)
76.: Kamimura D, Y Sawa, M Sato, E Agung, T Hirano, M Murakami#. (#, correspondence) IL-2 in vivo activities and anti-tumor efficacy enhanced by an anti-IL-2 mAb. J. Immunol. 177: 306-314, 2006 (PubMed)
75.: Sawa S, D Kamimura, G Jin, H Morikawa, H Kamon, M Nishihara, K Ishihara, M Murakami, T Hirano. Autoimmune arthritis associated with mutated IL-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J. Exp. Med. 203: 1459-1470, 2006. published on line 22 May 2006, 10.1084/jem.20052187.(PubMed) (J Exp Med) (In This Issue of JEM) (Research Highlights in Nature Reviews Immunology )
74.: Hirano T, M. Murakami. Grasp a pTyr-peptide by its SOCS. Dev. Cell 10: 542-544, 2006 (PubMed) (Review)

2005

73.: Kitamura, H., H. Kamon, S. Sawa, S-J. Park, N. Katsunuma, K. Ishihara, M. Murakami and T. Hirano. IL-6-STAT3 controls intracellular MHC classII ab-dimer level through Cathepsin S activity in dendritic cells. Immunity, 23: 491-502, 2005. (PubMed). (Immunity) (Science's STKE) (Research Highlights in Nature Immunology)

2004

72.: Kamimura D, Ueda N, Hachida S, Atsumi T, Nakagawa T, Sawa S, Suzuki H, Ishihara K, Murakami M, Hirano T. Evidence of a novel IL-2/15Rbeta-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells. J. Immunol. 173: 6041-6049, 2004. (PubMed).
71.: Park S, Nakagawa T, Kitamura H, Atsumi T, Kamon H, Sawa S, Kamimura D, Ueda N, Iwakura Y, Ishihara K, Murakami M, Hirano T. IL-6 Regulates in vivo Dendritic Cell Differentiation through STAT3 Activation. J. Immunol. 173：3844-3854, 2004. (PubMed)
70.: Ishihara K, Sawa S, Ikushima H, Hirota S, Astumi T, Kamimura D, Park S, Murakami M, Kitamura Y, Iwakura Y, Hirano T. The point mutation of Y759 of the IL-6 family receptor gp130 synergizes with HTLV-1 pX in promoting RA-like arthritis. Int. Immunol. 16: 455-465, 2004. (PubMed) (Int. Immunol)
69.: Murakami M, Kamimura D, Hirano T. New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27. Growth Facotrs 22: 75-77, 2004. (Review)

2003

68.: Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nature Immunology, 4: 551-556, 2003. (PubMed).

Before 2003

67.: Yamashita K, Masunaga T, Yanagida N, Takehara M, Hashimoto T, Kobayashi T, Echizenya H, Hua N, Fujita M, Murakami M, Furukawa H, Uede T, Todo S. Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies. Transplantation 15;76:1089-96. 2003.
66.: Tosa N, Murakami M, Jia WY, Yokoyama M, Masunaga T, Iwabuchi C, Inobe M, Iwabuchi K, Miyazaki T, Onoe K, Iwata M, Uede T. Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int Immunol. 15, 741-749, 2003.
65.: Kanaya K, Tsuchida Y, Inobe M, Murakami M, Hirose T, Kon S, Kawaguchi S, Wada T, Yamashita T, Ishii S, Uede T. Combined gene therapy with adenovirus vectors containing CTLA4Ig and CD40Ig prolongs survival of composite tissue allografts in rat model. Transplantation 75, 275-81, 2003.
64.: Nagamori M, Kawaguchi S, Murakami M, Wada T, Nagoya S, Yamashita T, Inobe M, Uede T.　Intrinsic and extrinsic manipulation of B7/CTLA-4 interaction for induction of anti-tumor immunity against osteosarcoma cells.　Anticancer Res. 22, 3223-3227, 2002.
63.: Nagamori M, Kawaguchi S, Murakami M, Wada T, Inobe M, Ishii S, Uede T. In vivo immunogenicity of osteosarcoma cells that express B7-1a, an alternatively spliced form of B7-1. Anticancer Res. 22, 2009-13, 2002.
62.: Swanson BJ, Murakami M, Mitchell1 TC, Kappler J, Marrack P. RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR dependent process. Immunity 17, 5, 605-615. 2002.
61.: Murakmi M, Sakamoto A, Bender J, Kappler J, Marrack P. CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc. Natl. Acad. Sci. U.S.A. 99, 8832-8837, 2002.
60.: Nomura M, Yamashita K, Murakami M, Takehara M, Echizenya H, Sunahara M, Kitagawa N, Fujita M, Furukawa H, Uede T, Todo S. Induction of donor-specific tolerance by adenovirus mediated CD40Ig gene therapy in rat liver transplantation. Transplantation 74, 1403-1410, 2002.
59.: Konishi K, Inobe M, Yamada A, Murakami M, Todo S, Uede T. Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative desease in a murine airway model. J Heart Lung Transplant. 21, 692-700, 2002.
58.: Iwasaki N, Gohda T, Yoshioka C, Murakami M, Inobe M, Minami A, Uede T. Feasibility of immunosuppression in composite tissue allografts. Transplantation 73, 334-40, 2002.
57.: Chiba S, Okamoto H, Kon S, Kimura C, Murakami M, Inobe M, Matsui Y, Sugawara T, Shimizu T, Uede T, Kitabatake A. Development of atherosclerosis in osteopontin transgenic mice. Heart and vesseles. 16,111-117, 2002.
56.: Ijima K, Murakami M, Okamoto H, Inobe M, Chikuma S, Saito I, Kanegae Y, Kawaguchi Y, Kitabatake A, Uede T. Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4IgG in a murine model of type II collagen-induced arthritis. Human Gene Therapy 12, 1063-77, 2001.
55.: Ueno H, Murakami M, Okumura M, Kadosawa T, Uede T, and Fujinaga T. Chitosan accelerates the production of osteopontin from polymorphonuclear leukocytes. Biomaterials 22, 1667-73, 2001.
54.: Takehara M, Murakami M, Nakagawa I, Saito I, Kanegae Y, Nomura M, Ohmura T, Todo S, Uede T. Long-term acceptance of　allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4Ig. Human Gene Therapy 12, 415-426, 2001.
53.: Nomura M, Yamashita K, Murakami M, Takehara M, Konishi M, Echizenya H, Yanagida N, Sunahara M, Kitagawa N, Furukawa H, Uede T, Todo S. Novel CD40-IgG adenovirus-mediated gene therapy as a potent immunosuppressive treatment for liver transplantation in rats. Transplant. Proc. 33, 189, 2001.
52.: Yanagida N, Nomura M, Yamashita K, Takehara M, Murakami M, Echizenya H, Konishi K, Kitagawa N, Furukawa H, Uede T, Todo S. Tolerance induction by a single donor pretreatment with the adenovirus vector encoding CTLA4Ig gene in rat orthotopic liver transplantation. Transplant. Proc. 33, 573-574, 2001.
51.: *Ku CC, *Murakami M, Sakamoto A, Kappler J, Marrack P. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288, 675-678, 2000. (*equal contribution)
50.: Marrack P, Bender J, Hildeman D, Jordan M, Mitchell T, Murakami M, Sakamoto A, Schaefer BC, Swanson B, Kappler J. Homeostasis of alpha and beta TCR+ T cells. Nature Immunol. 2, 107-111, 2000. (Review)
49.: Chikuma S, Murakami M, Tanaka K, Uede T. Janus Kinase 2 is associated with box 1-like motif and phosphrylates a critical tyrosine residue in the cytoplasmic region of CTLA-4. J. Cell. Biochem. 78, 241-250, 2000.
48.: Chiba S, Rashid MM, Okamoto H, Shiraiwa H, Kon S, Maeda M, Murakami M, Inobe M, Kitabatake A, Chambers AF, Uede T. The role of osteopontin in the development of granulomatous lesions in lung. Microbiol. Immunol. 44, 319-332, 2000.
47.: Takiguchi M, Murakami M, Nakagawa I, Rashid MM, Tosa N, Chikuma S, Hashimoto A, Uede T. Involvement CD28/CTLA4-B7 costimulatory pathway in the development of lymphadenopathy and splenomegary in MRL/lpr mice. J. Vet. Med. Sci. 62, 29-36, 2000.
46.: Yamada A, Konishi K, Crus GL, Takehara M, Morikawa M, Nakagawa I, Murakami M, Abe T, Todo S, Uede T.　Blocking the CD28-B7 T-cell costimulatory pathway abrogates the development of obliterative bronchiolitis in a murine heterotopic airway model. Transplantation 69, 743-749, 2000.
45.: Harada H, Ishikura H, Nakagawa I, Shindou J, Murakami M, Uede T, Koyanagi I, Yoshiki T. Donor-specific prolongation of survival of rat renal allografts by preoperative inoculation of CTLA4Ig plus allogeneic dendritic cells. Urol. Res. 28, 69-74, 2000.
44.: Yamashita K, Nomura M, Omura T, Takehara M, Suzuki T, Shimamura T, Kishida A, Furukawa H, Murakami M, Uede T, Todo S. Effect of a novel immunosuppressant, FTY720, on heart and liver transplantations in rats. Transplant. Proc. 31, 1178-1179, 1999.
43.: Takiguchi M, Murakami M, Nakagawa I, Yamada A, Chikuma S, Kawaguchi Y, Hashimoto A, Uede T. Blockade of CD28/CTLA4-B7 costimulatory pathway prevented autoantibody-related diseases but not lung diseases in MRL/lpr mice. Life Science 79, 317-326, 1999.
42.: Sato J, Asakura K, Murakami M, Uede T, Kataura A. Topical CTLA4Ig suppresses ongoing mucosal immune response in presensitized murine model of allergic rhinitis. Int. Aarch. Allergy Immunol. 119, 197-200, 1999.
41.: Takiguchi M, Murakami M, Nakagawa I, Yamada A, Chikuma S, Hashimoto A, Uede T. Blockade of CD28/CTLA4-B7 pathway prevented lymphadenopacy in MRL/lpr mice. Laboratory Investigation 79, 317-326, 1999.
40.: Tarumi K, Murakami M, Yagihashi A, Nakagawa I, Hirata K, Uede T. CTLA4IgG treatment induces long-term acceptance of rat small bowel allografts. Transplantation 67, 520-525, 1999.
39.: Katagiri Y, Sleeman, T, Fujii H, Herlich P, Hotta H, Tanaka K, Chikuma S, Yagita H, Okumura K, Murakami M, Saiki I, Chambers A, Uede T. CD44 variants but not CD44s cooperate with b1-containing integrins to permit cells to bind to osteopontin independently of RGD, there by stimulating cell motility and chemotaxis. Cancer Res. 59,　219-226, 1999.
38.: Aoki N, Inobe M, Murakami M, Abe R, Iizuka H. The functional role of B7 molecules on the induction of thymocyte activation and apoptosis. Microbiol. Immunol. 42, 5555-5565, 1998.
37.: Isashi Y, Yamashita T, Nagasawa S, Tanaka K, Murakami M, Uede T. The mechanism by which proteolysis enhances the ligand-binding activity of guinea pig type II Fc receptor for IgG (FcgRII). J. Biochem. 123, 959-967, 1998.
36.: Fujii H, Inobe M, Hayakawa Y, Kimura F, Murakami M, Ohnishi Y, Azuma I, Uede T, Saiki I. Vaccination with B7-1+ tumor and antiadhesion therapy with RGD pseudo-peptide (FC-336) efficiently induce　anti-metastatic effect. Clin. Exp. Metastasis 16, 141-148, 1998.
35.: Tarumi K, Yagihashi A, Murakami M, Uede T. Hirata K. Prolongation of rat small bowel allograft survival by CTLA4Ig. Transplant. Proc. 30, 2596-2599, 1998.
34.: Iizuka J, Katagiri Y, Tada N, Murakami M, Ikeda T, Sato M, Hirokawa K, Okada S, Hatano M, Tokuhisa T, Uede T. Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies. Laboratory Investigation 78, 1523-1533.
33.: Nakagawa I, Murakami M, Ijima K, Chikuma S, Saito I, Kanegae Y, Ishikura H Yoshiki T, Okamoto H, Kitabatake A, Uede T. Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG. Human Gene Therapy 9, 1739-1745, 1998.
32.: Hakamida-Taguchi R, Kato T, Ushijima H, Murakami M, Uede T, Nariuchi H. Expression and co-stimulatory function of B7-2 on murine CD4+ T cells. Eur. J. Immunol. 28, 865-873, 1998.
31.: Fukumoto T, Torigoe N, Kawabata S, Murakami M, Uede T, Nishi T, Ito Y, Sugimura K. Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation. Nature Biothechnology 16, 267-270, 1998.
30.: Kaneda R, Iwabuchi K, Kasai M, Murakami, M, Uede T, Onoe K. Selective antigen presenting activity of cortical thymic epithelial cells against CD4+ T cells associated with both lack of　costimulatory molceules and in efficient presentation of MHC-peptide ligands. Cell.Immunol. 181, 163-171, 1997.
29.: Uede T, Katagiri Y, Iizuka J, Murakami M. Osteopontin,　a cordinator of host defense system: a cytokine or an extracellular adhesive protein? Microbiol. Immunol. 41, 641-648, 1997. (Review)
28.: Tsuchida T, Usui M, Murakami M, Uede T. Vascularized bone marrow allotransplantation in rats prolong the survival of simultaneously grafted alloskin, Transplantation Proc. 29, 1732-1733, 1997.
27.: Tsuchida T, Naitoh T, Takahashi T, Usui M, Murakami M, Uede T. Limb allografts in rats treated with anti-ICAM1 and anti-LFA1 monoclonal antibodies. J. Recconst. Microsurg. 13, 107-110, 1997.
26.: Hara T, Murakami M, Maeda H, Hibi M, Uede T. Involvement of common 10 amino acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated responses. Biochem. Biophys. Res. Commun. 233, 187-192, 1997.
25.: Hayakawa M, Kwaguchi S, Ishii S, Murakami M, Uede T. B7-1-transfected tumor vaccine counteracts chemoterapy-induced immunosuppression and prolongs the survival of rats bearing highly metastatic osteosarcoma cells. Int. J. Cancer 72, 1-12, 1997.
24.: Murakami M, Takahashi Y, Isashi Y, Kon S, Inobe M, Abe R. Uede T. Identification and characterization of an alternative CTLA4 binding molecule on B cells. Proc. Natl. Acad. Sci., U.S.A. 93, 7838-7842, 1996.
23.: Yamada A, Murakami M, Ijima K, Yagita H, Okumura K, Komatsu S, Uede T. Long-term acceptance of major histocompatibility　complex-mismached cardiac allograft induced by a low dose of CTLA4IgM plus FK506. Microbiol. Immunol. 40, 513-518, 1996.
22.: Isashi Y, Yamashita T, Nagasawa S, Murakami M, Uede T. Molecular cloning and characterization of gunia-pig FcgRIII: expression but not function is independent of the g chain of FceRI. Int. Immunol. 8, 1335-1346, 1996.
21.: Katagiri Y, Murakami M, Mori K, Iizuka J, Hara T, Tanaka K, Jia WY, Chambers AF, Uede T. Non-RGD domains of osteopontin promote cell adhesion without involving aV integrins. J. Cell Biochem. 62, 123-131, 1996.
20.: Inobe M, Aoki N, Linsley PS, Ledbetter JA, Murakami M, Uede, T. The role of B7-1a molecule, an alternatively spliced form of murine B7-1, on T cell activation. J. Immunol. 157, 582-588, 1996.
19.: Fujii H, Inobe M, Kimura F, Murata J, Murakami M, Onishi Y, Azuma I, Uede T, Saiki I. Vaccination of tumor cells transfected with B7-1 (CD80) gene induces the anti-metastatic effect and tumor immunity in mice. Int. J. Cancer 66, 219-224, 1996.
18.: Toyooka K, Maruo S, Iwahori T, Yamamoto N, Tai XG, Abe R, Takahama Y, Murakami M, Uede T, Hamaoka T Fujiwara H. CD28 costimulatory signals induce IL-2 receptor expression on antigen stimulated virgin T cells by an IL-2-independent mechanisms. Int. Immunol. 8, 159-169, 1995.
17.: Isashi Y, Tamakoshi M, Nagai Y, Sudo T, Murakami M, Uede T. The rat neutrophil low affinity Fc receptor for IgG: Moleculare cloning and functional characterization. Immunology letters 46, 157-163, 1995.
16.: Yoneya K, Okamoto H, Machida M, Onozuka H, Noguchi M, Mikami T, Kawaguchi H, Murakami M, Uede T, Kitabatake A. Angiotensin-converting enzyme gene polymorphism in japanese patients with hypertrophic cardiomypathy. American Heart J. 130, 1089-1093, 1995.
15.: Kamikubo Y, Murakami M, Imamura M, Murashita T, Yasuda K, Uede T. Neutrophil-independent myocardial dysfunction during an early stage of global ischemia and repurfusion of isolated hearts. Immunopharmacology 29, 261-271, 1995.
14.: Katagiri Y, Mori K, Hara T, Tanaka K, Murakami M, Uede T. Functional analysis of osteopontin molecule. Ann. N. Y. Acad. Sci. 760, 371-374, 1995.
13.: Murakami M, Hibi M, Nakagawa T, Yasukawa K, Yamanishi K, Taga T, Kishimoto T. IL-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 160, 1808-1810, 1993.
12.: Yawata H, Yasukawa K, Nastuka S, Murakami M, Yamasaki H, Hibi M, Taga T Kishimoto T. Structure-function analysis of human IL-6 receptor: disscciation of amino acid residues required for IL-6 binding and for IL-6 siganl transduction through gp130. EMBO J. 12, 1705-1712, 1993.
11.: Kishimoto T, Hibi M, Murakami M, Narazaki M, Saito M Taga T. The molecular bioloby of interleukin 6 and its receptor. In Polyfunctional cytokines: IL-6 an LIF, edt. by Gregory R. Bock, Joan Marsh (Organizers) and Kate Widdows, John Wiley & Sons, Chichester. p.5-23, 1992. (Review)
10.: Falus A, Hibi M, Murakami M, Taga T Kishimoto T. Regulation of IL-6 receptor and gp130 expression on human cell lines of lymphoid myeloid origin. Cytokine 4, 495-499, 1992.
9.: Taga T, Hibi M, Murakami M, Saito M, Yawata H, Narazaki M, Hirata Y, Sugita T, Yasukawa K, Hirano T, Kishimoto T. Interleukin 6 receptor and signals. Chem. Immunol. 51:181-204, 1992. (Review)
8.: Liu J, Modrell B, Aruffo A, Marken JS, Taga T, Yasukawa K, Murakami M, Kishimoto T. Shoyab M. Interleukin-6 signal transducer gp130 mediates Oncostatin M signaling. J. Biol. Chem. 267, 16763-16766, 1992.
7.: Kishimoto T, Hibi M, Murakami M, Narazaki M, Saito M, Taga T. The molecular biology of interleukin 6 and its receptor. Chiba-Found-Symp. 167, 5-23, 1992. (Review)
6.: Taga T, Hibi M, Murakami M, Saito M, Yawata H, Narazaki M, Hirata Y, Sugita T, Yasukawa K, Hirano T, Kishimoto T. IL-6 receptor and signals. In Chemical Immunology: Interleukins: MolecularBiology and Immunology, ed. by Kishimoto, T., and S. Karger AG, Basel Switzerland. vol. 51, p181-204, 1992. (Review)
5.: Murakami M, Narazaki M, Hibi M, Yawata H, Yasukawa K, Hamaguchi M, Taga T. Kishimoto T. Critical cytoplasmic region of the IL-6 signal transducer, gp130, is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. U.S.A. 88, 11349-11353, 1991
4.: Taga T, Hibi M, Murakami M, Saito M, Hirano T Kishimoto, T. A new cytokine receptor family ans a novel signaling mechanism by receptor-associate IL-6 signal transducer, gp130. In Origins Human Cancer: A comprehensive Review. Cold Spring Harver Lab. Press, NY, USA. 277-284, 1991. (Review)
3.: Hibi M, Murakami M, Saito M, Hirano T, Taga T Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63, 1149-1157, 1990.
2.: Hirano T, Taga T, Matsuda T, Hibi M, Suematsu S, Tang B, Murakami M, Kishimoto T. Interleukin 6 and its receptor in the immune response and hematopoiesis. Int. J. Cell Cloning 8:155-167, 1990. (Review)
1.: Suematsu S, Hibi M, Sugita T, Saito M, Murakami M, Matsusaka T, Matsuda T, Hirano T, Taga T, Kishimoto T. Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma. In Current topics in microbiology and immunology Vol. 166, edt. by M. Potter and F. Melchers, Springer-Verlag Berlin Heidelberg. p.13-22, 1990. (Review)