HomeCurriculum Vitae

Curriculum Vitae

村上正晃 写真

Masaaki Murakami, V.M.D., Ph.D.

Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University
Office Address: Kita-15, Nishi-7, Kitaku, Sapporo, Japan
Phone Number: +81-11-706-5120, +81-11-706-5524
Email Address: murakami@igm.hokudai.ac.jp

Education

1993 Ph.D. Immunology
Osaka University, Osaka, Japan
Thesis Title: “Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family”
1989 V.M.D. Veterinary Medicine
Hokkaido University, Sapporo, Japan

Research Experience

2016-present
Sapporo, Japan		 Director, Institute for Genetic Medicine, Hokkaido University
2014-present
Sapporo, Japan		 Professor, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University
(Analyses of chronic inflammation: the inflammation loop in non-immune cells and the gateway theory)
2007 to 2014
Osaka, Japan		 Associate Professor, Graduate School of Frontier Biosciences, Osaka University
(Analyses of the inflammation amplifier in vivo)
2002 to 2007
Osaka, Japan		 Associate Professor, Graduate School of Medicine, Osaka University
(Analyses of cytokine-mediated arthritis)
2001-2002 to 2003
Denver, Colorado, The U.S.		 Visiting Associate Professor, Integrated Department of Immunology, Colorado University
(Analyses of memory T cell maintenance)
1999 to 2001
Denver, Colorado, The U.S.		 JST Postdoctoral Fellow for Research Abroad, HHMI, National Jewish Medical and Research Center
(Analyses of cytokine-mediated memory T cell maintenance)
1993 to 1999
Sapporo, Japan		 Assistant Professor, Institute of Immunological Science, Hokkaido University
(Analyses of costimulation in T cell activation)

Honors and Awards including Grants Awarded

(reverse chronological order)

  1. Frontier 2013 award, Frontier Immunology, 2013
  2. Frontier 2012 award, Frontier Immunology, 2012
  3. Grant in aid of the Uehara memorial foundation, the Uehara memorial foundation, 2012
  4. Grant in aid of the Naito foundation, the Naito foundation, 2012
  5. Grant in aid of Waksman foundation of Japan, Waksman foundation of Japan, 2012
  6. Grant in aid of Mochida memorial foundation for medical and pharmaceutical research, Mochida memorial foundation for medical and pharmaceutical research, 2012
  7. Grant in aid of Takeda science foundation, Takeda science foundation, 2012
  8. Grant in aid of the Tokyo biomedical research foundation, the Tokyo biomedical research foundation, 2012
  9. Grant in aid of Osaka foundation for cancer research, Osaka foundation for cancer research, 2012
  10. Grant in aid of the Osaka foundation for promotion of clinical immunology, the Osaka foundation for promotion of clinical immunology, 2003-2012
  11. Grant in aid of the Nakatomi foundation, the Nakatomi foundation, 2007
  12. Grant in aid of the Uehara memorial foundation, the Uehara memorial foundation, 2007
  13. Grant in aid of Osaka cancer society, Osaka cancer society, 2002-2003
  14. Grant in aid of the Uehara memorial foundation, the Uehara memorial foundation, 2002
  15. Grant in aid of Kanae Foundation for the promotion of medical science, Kanae Foundation for the promotion of medical science, 2002
  16. Grant in aid of Mochida memorial foundation for medical and pharmaceutical research, Mochida memorial foundation for medical and pharmaceutical research, 2001
  17. JST Postdoctoral Fellow for Research Abroad, Japan Society for the Promotion of Science 1999

Committee Service

Publication List

  1. Hashimoto, S., S. Furukawa, A. Hashimoto, A. Tsutaho, A. Fukao, Y. Sakamura, G. Parajuli, Y. Onodera, Y. Otsuka, H. Handa, T. Oikawa, S. Hata, Y. Nishikawa, Y. Mizukami, Y. Kodama, M. Murakami, T. Fujiwara, S. Hirano, and H. Sabe. ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer. PNAS 2019 Aug 9. pii: 201901765. doi: 10.1073/pnas.1901765116.
  2. Nishida, K., A. Hasegawa A, S. Yamasaki, R. Uchida, W. Ohashi, Y. Kurashima, J. Kunisawa, S. Kimura, T. Iwanaga, H. Watarai, K. Hase, H. Ogura, M. Nakayama, JI Kashiwakura, Y. Okayama, M. Kubo, O. Ohara, H. Kiyono, H. Koseki, M. Murakami, and T. Hirano. Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis. Sci Rep. 2019 Jul 25;9(1):10842. doi: 10.1038/s41598-019-47132-5.
  3. Tanaka, H., Y. Arima, D. Kamimura, Y. Tanaka, N. Takahashi, T. Uehata, K. Maeda, T. Satoh, M. Murakami, and S. Akira. Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response. J Exp Med. Jun 3;216(6):1431-1449, 2019.
  4. Stofkova, A., D. Kamimura, T. Ohki, M. Ota, Y. Arima, and M. Murakami. Photopic light-mediated down-regulation of local α1A-adrenergic signaling protects blood-retina barrier in experimental autoimmune uveoretinitis. Sci Rep. 9, Article number: 2353, 2019.
  5. Fujita, M., Y. Yamamoto, J-J. Jiang, T. Atsumi, Y. Tanaka, T. Ohki, N. Murao, E. Funayama, T. Hayashi, M. Osawa, T. Maeda, D. Kamimura, and M. Murakami. NEDD4 is involved in inflammation development during keloid formation. J Invest Dermatol. 139, 333-341, 2019.
  6. Tanaka, Y.*, L. Sabharwal* (Equal contribution), M. Ota, I. Nakagawa, J-J. Jiang, Y. Arima, H. Ogura, M. Okochi, 　M. Ishii, D. Kamimura# and M. Murakami# (#Corresponding authors). Presenilin 1 regulates NF-κB activation via association with breakpoint cluster region and casein kinase II. J Immunol. Oct 15;201(8):2256-2263, 2018. doi: 10.4049/jimmunol.1701446.
  7. Okuyama, Y.*, Y. Tanaka*, J-J. Jiang*, D. Kamimura*# (*Equal contribution, #Corresponding authors), A. Nakamura, M. Ota, T. Ohki, D. Higo, H. Ogura, N. Ishii, T. Atsumi and M. Murakami#. Bmi1 regulates IkBa degradation via association with the SCF complex. J Immunol. Oct 15;201(8):2264-2272, 2018. doi: 10.4049/jimmunol.1701223.
  8. Tainaka, K., TC. Murakami, EA. Susaki, C. Shimizu, R. Saito, K. Takahash, A. Hayashi-Takagi, H. Sekiya, Y. Arima, S. Nojima, M. Ikemura, T. Ushiku, Y. Shimizu, M. Murakami, KF. Tanaka, M. Iino, H. Kasai, T. Sasaoka, K. Kobayashi, K. Miyazono, E. Morii, T. Isa, M. Fukayama, A. Kakita, and HR. Ueda. Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents. Cell Rep. 2018 Aug 21;24(8):2196-2210.e9. doi: 10.1016/j.celrep.2018.07.056.
  9. Itabashi, T., Y. Arima, D. Kamimura, K. Higuchi, Y. Bando, H. Takahashi-Iwanaga, M. Murakami, M. Watanabe, and T. Iwanaga. Cell- and stage-specific localization of galectin-3, a beta-galactoside-binding lectin, in a mouse model of experimental autoimmune encephalomyelitis. Neurochem Int. 118: 176-184, 2018. doi: 10.1016/j.neuint.2018.06.007.
  10. Kijimoto-Ochiai, S., T. M-Mizuno, D. Kamimura, M. Murakami, M. Kobayashi, I Matsuoka, H. Ochiai, H. Ishida, M. Kiso, K. Kamimura, and T. Koda. Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5. Glycobiology 28(5): 306-317, 2018 doi: 10.1093/glycob/cwy009 (Impact Factor 3.1)
  11. Atsumi, T., H. Suzuki, J-J. Jiang, Y. Okuyama, I. Nakagawa, M. Ota, Y. Tanaka, T. Ohki, K. Katsunuma, K. Nakajima, Y. Hasegawa, O. Ohara, H. Ogura, Y. Arima, D. Kamimura, and M. Murakami. Rbm10 regulates inflammation development via alternative splicing of Dnmt3b. Int Immunol. 29(12):581-591, 2017. doi: 10.1093/intimm/dxx067. (Impact Factor 3.7)
  12. Arima, Y., T. Ohki, N. Nishikawa, K. Higuchi, M. Ota, Y. Tanaka, J. Nio-Kobayashi, M. Elfeky, R. Sakai, Y. Mori, T. Kawamoto, A. Stofkova, Y. Sakashita, Y. Morimoto, M. Kuwatani, T. Iwanaga, Y. Yoshioka, N. Sakamoto, A. Yoshimura, M. Takiguchi, S. Sakoda, M. Prinz, D. Kamimura, and M. Murakami. Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit. eLife 6: e25517 DOI: 10.7554/eLife.25517, 2017. (Impact Factor 8.5)
  13. Tanaka, Y., Y. Arima, K. Higuchi, T. Ohki, M. Elfeky, M. Ota, D. Kamimura and M. Murakami. EAE Induction by Passive Transfer of MOG-specific CD4+ T Cells. Bio-protocol. 7(13), 7/5/2017, DOI: https://doi.org/10.21769/BioProtoc.2370, 2017. (Impact Factor N/A)
  14. Kitada, S. H. Kayama, D. Okuzaki, R. Koga, M. Kobayashi, Y. Arima, A. Kumanogoh, M. Murakami, M. Ikawa and K. Takeda. BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. J Exp. Med. 214(5):1313-1331, 2017. (Impact Factor 12.0)
  15. Meng, J.*, J-J Jiang* (*Equal contribution), T. Atsumi, H. Bando, Y. Okuyama, L. Sabharwal, I. Nakagawa, H. Higuchi, M. Ota, M. Okawara, R. Ishitani, O. Nureki, D. Higo, Y. Arima, H. Ogura, D. Kamimura and M. Murakami. Breakpoint cluster region-mediated inflammation is dependent on casein kinase II. J Immunol. 197(8), 3111-3119, 2016. (Impact Factor 4.9)
  16. Kamimura, D., Y. Arima, M. Tsuruoka, J-J Jiang, H. Bando, J. Meng, L. Sabharwal, A. Stofkova, N. Nishikawa, K. Higuchi, H. Ogura, T. Atsumi, M. Murakami. Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naïve T cells. Int Immunol. 28(3), 117-126, 2016. (Impact Factor 3.7)
  17. Nakanishi, K., M. Nishida1, M. Harada, T. Ohama, N. Kawada, M. Murakami, T. Moriyama1, K. Yamauchi-Takihara. Klotho-related molecules upregulated by smoking habit in apparently healthy men: A crosssectional study. Sci Rep. 5; 14230, 2015. (Impact Factor 5.6)
  18. Arima, Y*., D. Kamimura* (*Equal contribution), T. Atsumi, M. Harada, T. Kawamoto, N. Nishikawa, A. Stofkova, T. Ohki, K. Higuchi, Y. Morimoto, P. Wieghofer, Y. Okada, Y. Mori, S. Sakoda, S. Saika, Y. Yoshioka, I. Komuro, T. Yamashita, T. Hirano, M. Prinz, M. Murakami. A pain-mediated neural signal induces relapse in multiple sclerosis models. eLife 2: e08733 2015. (Impact Factor 8.5)
  19. Ito, D., S. Nojima, M. Nishide, T. Okuno, H. Takamatsu, S. Kang, T. Kimura, Y. Yoshida, K. Morimoto, Y. Maeda, T. Hosokawa, T. Toyofuku, J. Ohshima, D. Kamimura, M. Yamamoto, M. Murakami, E. Morii, H. Rakugi, Y. Isaka, A. Kumanogoh. mTOR complex signaling through the SEMA4A-Plexin B2 axis is required for optimal activation and differentiation of CD8+ T cells. J Immunol. 20195(3):934-43, 2015 (Impact Factor 5.5)
  20. Hashimoto-Kataoka, T., N. Hosen, T. Sonobe, Y. Arita, T. Yasui, T. Masaki, M. Minami, T. Inagaki, S. Miyagawa, Y. Sawa, M. Murakami, A. Kumanogoh, K. Yamauchi-Takihara, M. Okumura, T. Kishimoto, I. Komuro, M. Shirai, Y. Sakata, Y. Nakaoka. Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension. Proc Natl Acad Sci USA. 2015 May 19;112(20):E2677-86. (Impact Factor 9.8)
  21. Kamimura, D.*#, K. Katsunuma*, Y. Arima, T. Atsumi, J-J Jiang, H. Bando, J. Meng, L. Sabharwal, A. Stofkova, N. Nishikawa, H. Suzuki, H. Ogura, N. Ueda, M. Tsuruoka, M. Harada, J. Kobayashi, T. Hasegawa, H. Yoshida, H. Koseki, I. Miura, S. Wakana, K. Nishida, H. Kitamura, T. Fukada, T. Hirano, and M. Murakami#. (*Equal contribution, #Equal correspondence), KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR. Nat. Commun. 6, Article number: 7474, doi:10.1038/ncomms8474, 2015 (Corresponding Author, Impact Factor 10.7)
  22. Maeda, K., T. Kosugi, W. Sato, H. Kojima, Y. Sato, D. Kamimura, N. Kato, N. Tsuboi, Y. Yuzawa, S. Matsuo, M. Murakami, S. Maruyama, K. Kadomatsu. CD147/Basigin limits lupus nephritis and TH17 cell differentiation by inhibiting the IL-6/STAT3 pathway. Arthritis Rheumatol. 6(2):120–128, 2015. (Impact Factor 7.9)
  23. Harada, M.*, D. Kamimura* (*, equal contribution),Y. Arima, H. Kohsaka, Y. Nakatsuji, M. Nishida, T. Atsumi, J. Meng, H. Bando*, R. Singh, L. Sabharwal, J-J. Jiang, N. Kumai, N. Miyasaka, S. Sakoda, K. Yamauchi-Takihara, H. Ogura, T. Hirano and M. Murakami. Temporal Expression of Growth Factors Triggered by Epiregulin Regulates Inflammation Development. J. Immunol. 194(3):1039-46, 2015 (Corresponding Author, Impact Factor 5.5)
  24. Hojyo, S., T. Miyai, H. Fujishiro, M. Kawamura, T. Yasuda, A. Hijikata, B. Bin, T. Irié, J. Tanaka, T. Atsumi, M. Murakami, M. Nakayama, O. Ohara, S. Himeno, H. Yoshida, H. Koseki, T. Ikawa, K. Mishima, and T. Fukada. Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B cell receptor signal strength. Proc. Natl. Acad. Sci. USA. 12;111(32):11786-91, 2014 (Impact factor 9.7)
  25. Mori, Y*., M. Murakami*, Y. Arima, D. Zhu, Y. Terayama, Y. Komai, Y. Nakatsuji, D. Kamimura, and Y. Yoshioka. (*equal contribution) Early pathological alterations of lower lumber cords detected by ultra-high field MRI in a mouse multiple sclerosis model. Int. Immunol. 26: 93-101, 2014 (Corresponding Author, Impact factor 3.1)
  26. Murakami, M., M. Harada, D. Kamimura, H. Ogura, Y. Okuyama, N. Kumai, A. Okuyama, R. Singh, J.-J. Jiang, T. Atsumi, S. Shiraya, Y. Nakatsuji, M. Kinoshita, H. Kohsaka, M. Nishida, S. Sakoda, N. Miyasaka, K. Yamauchi-Takihara and T. Hirano. Disease-association analysis of an inflammation-related feedback loop. Cell Reports 3: 1-14, 2013. http://dx.doi.org/10.1016/j.celrep.2013.01.028, 2013. (Corresponding Author, Impact factor N/A)
  27. Kusu,T., H. Kayama, M. Kinoshita, S. Gyu-Jeon, Y. Ueda, Y. Goto, R. Okumura, H. Saiga, T. Kurakawa, K. Ikeda, Y. Maeda, J. Nishimura, Y. Arima, K. Atarashi, K. Honda, M. Murakami, J. Kunisawa, H. Kiyono, M. Okumura, M. Yamamoto and K. Takeda. Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine. J. Immunol. 190: 774-783, 2013. (Impact factor 5.5)
  28. Sasaki, M., A. Tojo, Y. Okochi, N. Miyawaki, D. Kamimura, A. Yamaguchi, M. Murakami and Y. Okamura. Autoimmune disorder phenotypes in HVCN1 gene deficient mice. Biochem. J. 450: 295-301, 2013. (Impact factor 4.7)
  29. Lee, J., T. Nakagiri, D. Kamimura, T. Oto, M. Harada, E. Morii, Y. Shintani, M. Inoue, S. Miyoshi, T. Hirano, M. Murakami and M. Okumura. IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation. Int. Immunol. 25: 319-332, 2013. (Corresponding Author, Impact factor 3.1)
  30. Arima, Y., M. Harada, D. Kamimura, J-H. Park, F. Kawano, F. E. Yull, T. Kawamoto, Y. Iwakura, U.A.K. Betz, G. Ma´rquez, T. S. Blackwell, Y. Ohira, T. Hirano and M. Murakami. Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier. Cell 148: 447-457, 2012. (Corresponding Author, Impact Factor 32.0)
  31. Kayama H., Y. Ueda, Y. Sawa, S. G. Jeon, J.S. Ma, R. Okumura, A. Kubo, M. Ishii, T. Okazaki, M. Murakami, M. Yamamoto, H. Yagita and K. Takeda. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. Proc. Natl. Acad. Sci. USA. 109: 5010-5015, 2012. (Impact factor 9.7)
  32. Lee, J., T. Nakagiri, T. Oto, M. Harada, E. Morii, Y. Shintani, M. Inoue, S. Miyoshi, M. Okumura, T. Hirano and M. Murakami. IL-6 amplifier, NFκB-triggered positive-feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses. J. Immunol. 189: 1928-1936, 2012. (Corresponding Author, Impact Factor 5.5)
  33. Murakami, M., Y. Okuyama, H. Ogura, S. Asano, Y. Arima, M. Tsuruoka, M. Harada, M. Kanamoto, Y. Sawa, Y. Iwakura, K. Takatsu, D. Kamimura and T. Hirano. Local microbleeding facilitates IL-6－ and IL-17－dependent arthritis in the absence of tissue antigen recognition by activated T cells. J. Exp. Med. 208: 103-114, 2011. (Impact factor 13.2)
  34. Verjan-Garcia, N., E. Umemoto, Y. Saito, M. Yamasaki, E. Hata, T. Matozaki, M. Murakami, YJ. Jung, SY. Woo, JY. Seoh, MH. Jang, K. Aozasa and M. Miyasaka. SIRPalpha/CD172a Regulates Eosinophil Homeostasis. J. Immunol. 187: 2268-2277, 2011. (Impact factor 5.5)
  35. Nakagawa T., M. Tsuruoka, H. Ogura, Y. Okuyama, Y. Arima, T. Hirano and M. Murakami. IL-6 positively regulates Foxp3+CD8+ T cells in vivo. Int. Immunol. 22:129-139, 2010. (Corresponding Author, Impact factor 3.1)
  36. Kitabayashi, C., T. Fukada, M. Kanamoto1, W. Ohashi, S. Hojyo, T. Atsumi, N. Ueda, I. Azuma, H. Hirota, M. Murakami and T. Hirano. Zinc suppresses Th17 development via inhibition of STAT3 activation. Int. Immunol. 22: 375-386, 2010. (Impact factor 3.1)
  37. Sawa Y., Y. Arima, H. Ogura, C. Kitabayashi, J-J Jiang, T. Fukushima, D. Kamimura, T. Hirano and M. Murakami. Hepatic Interleukin-7 Expression Regulates T Cell Responses. Immunity 30: 447-457, 2009. (Corresponding Author, Impact factor 19.8)
  38. Atsumi, T., M. Sato, D. Kamimura, A. Moroi, Y. Iwakura, U. A. K. Betz, A. Yoshimura, M. Nishihara, T. Hirano and M. Murakami. IFN-γ expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death. Int. Immunol. 21:73-80, 2009. (Corresponding Author, Impact factor 3.1)
  39. *Ogura, H, *M. Murakami, Y. Okuyama, M. Tsuruoka1, C. Kitabayashi, M. Kanamoto, M. Nishihara, Y. Iwakura and T. Hirano. (*equal contribution) Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction. Immunity 29: 628-636, 2008. (Impact factor 19.8)
  40. Jin, G., T. Hirano and M. Murakami. Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation. Int. Immunol. 20: 783-789, 2008. (Corresponding Author, Impact factor 3.1)
  41. Tanaka, Y., N. Tanaka, Y. Saeki, K. Tanaka, M. Murakami, T. Hirano, N. Ishii and K. Sugamura. c-Cbl-dependent Monoubiquitination and Lysosomal Degradation of gp130. Mol. Cell. Biol. 28: 4805-4818, 2008. (Impact factor 5.4)
  42. *Khiong, K., *M. Murakami, C. Kitabayashi, N. Ueda, S. Sawa, A. Sakamoto, B. L. Kotzin, S. J. Rozzo, K. Ishihara, M. Verella-Garcia, J. Kappler, P. Marrack and T. Hirano. (*equal contribution). Homeostatic proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J. Clin. Invest. 117: 1270-1281, 2007. (Corresponding Author, Impact factor 12.8)
  43. Nishihara, M., H. Ogura, N. Ueda, M. Tsuruoka, C. Kitabayashi, F. Tuji, H. Aono, K. Ishihara, E. Huseby, U. A.K.Betz, M. Murakami and T. Hirano. IL-6-gp130-STAT3 in T cells directs the development of IL-17+T helper cells with a minimum effect on that of Treg in the steady state. Int. Immunol. 19: 695-702, 2007. (Impact factor 3.1)
  44. Sawa, S., D. Kamimura, G.-H. Jin, H. Morikawa, H. Kamon, M. Nishihara, K. Ishihara, M. Murakami and T. Hirano. Autoimmune arthritis associated with mutated IL-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J. Exp. Med. 203: 1459-1470, 2006. (Impact factor 13.2)
  45. Kamimura, D., Y. Sawa, M. Sato, E. Agung, T. Hirano and M. Murakami. IL-2 in vivo activities and anti-tumor efficacy enhanced by an anti-IL-2 mAb. J. Immunol. 177: 306-314, 2006. (Corresponding Author, Impact factor 5.5)
  46. Kitamura, H., H. Morikawa, H. Kamon, M. Iguchi, S. Hojyo, T. Fukada, S. Yamashita, T. Kaisho, S. Akira, M. Murakami and T. Hirano. Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nature Immunol. 7: 971-977, 2006. (Impact factor 26.2)
  47. Ueda, N., H. Kuki, D. Kamimura, S. Sawa, K. Seino, M. Taniguchi, T. Hirano and M. Murakami. CD1d-restricted natural killer T cell activation enhanced homeostatic proliferation of CD8+T cells in a manner dependent on IL-4. Int. Immunol. 18: 1397-1404, 2006. (Corresponding Author, Impact factor 3.1)
  48. Kamon, H., T. Kawabe, H. Kitamura, D. Kamimura, G.-H. Jin, T. Kaisyo, S. Akira, A. Iwamatsu, H. Koga, K. Ishihara, M. Murakami and T. Hirano. TRIF-GEFH1-RhoB cascade regulates surface expression of MHC class II in dendritic cells that is critical for CD4+ T cell activation. EMBO J. 25:4108-4119, 2006. (Impact factor 9.8)
  49. Kitamura, H., H. Kamon, S. Sawa, S-J. Park, N. Katsunuma, K. Ishihara, M. Murakami and T. Hirano. IL-6-STAT3 controls intracellular MHC classII ab-dimer level through Cathepsin S activity in dendritic cells. Immunity 23: 491-502, 2005. (Impact factor 19.8)
  50. Ishihara, K., S. Sawa, H. Ikushima, S. Hirota, T. Astumi, D. Kamimura, S.-J. Park, M. Murakami, Y. Kitamura, Y. Iwakura and T. Hirano. The point mutation of Y759 of the IL-6 family receptor gp130 synergizes with HTLV-1 pX in promoting RA-like arthritis. Int. Immunol. 16: 455-465, 2004. (Impact factor 3.1)
  51. Park, S-J., T. Nakagawa, H. Kitamura, T. Atsumi, H. Kamon, S. Sawa, D. Kamimura, N. Ueda, Y. Iwakura, K. Ishihara, M. Murakami and T. Hirano. IL-6 Regulates in vivo Dendritic Cell Differentiation through STAT3 Activation. J. Immunol. 173: 3844-3854, 2004. (Impact factor 5.5)
  52. Mizutani, T., S. Fukushi, M. Murakami, T. Hirano, M. Saijo, I. Kurane and S. Morikawa. Tyrosine dephosphorylation of STAT3 in SARS coronavirus-infected Vero E6 cells. FEBS Letters 577: 187-192, 2004. (Impact factor 3.6)
  53. Kamimura, D., N. Ueda, S. Hachida, T. Atsumi, T. Nakagawa, S. Sawa, H. Suzuki, K. Ishihara, M. Murakami and T. Hirano. Evidence of a novel IL-2/15Rbeta-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells. J. Immunol. 173: 6041-6049, 2004. (Impact factor 5.5)
  54. Mori, T., M. Murakami, M. Okumura, T. Kadosawa, T. Uede and T. Fujinaga. Mechanism of macrophage activation by chitin derivatives. J. Vet. Med. Sci. 67: 51-56, 2004. (Impact factor 0.9)
  55. Kanaya, K., Y. Tsuchida, M. Inobe, M. Murakami, T. Hirose, S. Kon, S. Kawaguchi, T. Wada, T. Yamashita, S. Ishii and T. Uede. Combined gene therapy with adenovirus vectors containing CTLA4Ig and CD40Ig prolongs survival of composite tissue allografts in rat model. Transplantation 75: 275-81, 2003. (Impact factor 3.8)
  56. Tosa, N., M. Murakami, W.Y. Jia, M. Yokoyama, T. Masunaga, C. Iwabuchi, M. Inobe, K. Iwabuchi, T. Miyazaki, K. Onoe, M. Iwata and T. Uede. Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis. Int Immunol. 15: 741-749, 2003. (Impact factor 3.1)
  57. Yamashita, K., T. Masunaga, N. Yanagida, M. Takehara, T. Hashimoto, T. Kobayashi, H. Echizenya, N. Hua, M. Fujita, M. Murakami, H. Furukawa, T. Uede and S. Todo. Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies. Transplantation 15: 76:1089-96. 2003. (Impact factor 3.8)
  58. Yasukawa, H., M. Ohishi, H. Mori, M. Murakami, T. Chinen, D. Aki, T. Hanada, K. Takeda, S. Akira, M. Hoshijima, T. Hirano, K.R. Chien and A. Yoshimura. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nature Immunol. 4: 551-556, 2003. (Impact factor 26.2)
  59. Chiba, S., H. Okamoto, S. Kon, C. Kimura, M. Murakami, M. Inobe, Y. Matsui, T. Sugawara, T. Shimizu, T. Uede and A. Kitabatake. Development of atherosclerosis in osteopontin transgenic mice. Heart and Vessels. 16: 111-117, 2002. (Impact factor 2.1)
  60. Iwasaki, N., T. Gohda, C. Yoshioka, M. Murakami, M. Inobe, A. Minami and T. Uede. Feasibility of immunosuppression in composite tissue allografts. Transplantation 73: 334-40, 2002. (Impact factor 3.8)
  61. Konishi, K., M. Inobe, A. Yamada, M. Murakami, S. Todo and T. Uede. Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative desease in a murine airway model. J Heart Lung Transplant. 21: 692-700, 2002. (Impact factor 4.3)
  62. Nomura, M., K. Yamashita, M. Murakami, M. Takehara, H. Echizenya, M. Sunahara, N. Kitagawa, M. Fujita, H. Furukawa, T. Uede and S. Todo. Induction of donor-specific tolerance by adenovirus mediated CD40Ig gene therapy in rat liver transplantation. Transplantation. 73: 1403-1410, 2002. (Impact factor 3.8)
  63. Murakmi, M., A. Sakamoto, J. Bender, J. Kappler and P. Marrack. CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc. Natl. Acad. Sci. U.S.A. 99: 8832-8837, 2002. (Impact factor 9.7)
  64. Swanson, B.J., M. Murakami, T. C. Mitchell1, J. Kappler and P. Marrack. RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR dependent process. Immunity 17: 605-615: 2002. (Impact factor 19.8)
  65. Nagamori, M., S. Kawaguchi, M. Murakami, T. Wada, M. Inobe, S. Ishii and T. Uede. In vivo immunogenicity of osteosarcoma cells that express B7-1a, an alternatively spliced form of B7-1. Anticancer Res. 22: 2009-13, 2002. (Impact factor 1.7)
  66. Nagamori, M., S. Kawaguchi, M. Murakami, T. Wada, S. Nagoya, T. Yamashita, M. Inobe and T. Uede. Intrinsic and extrinsic manipulation of B7/CTLA-4 interaction for induction of anti-tumor immunity against osteosarcoma cells. Anticancer Res. 22: 3223-3227, 2002. (Impact factor 1.7)
  67. Yanagida, N., M. Nomura, K. Yamashita, M. Takehara, M. Murakami, H. Echizenya, K. Konishi, N. Kitagawa, H. Furukawa, T. Uede and S. Todo.  Tolerance induction by a single donor pretreatment with the adenovirus vector encoding CTLA4Ig gene in rat orthotopic liver transplantation. Transplant. Proc. 33: 573-574, 2001. (Impact factor 1.0)
  68. Nomura, M., K. Yamashita, M. Murakami, M. Takehara, M. Konishi, H. Echizenya, N. Yanagida, M. Sunahara, N. Kitagawa, H. Furukawa, T. Uede and S. Todo. Novel CD40-IgG adenovirus-mediated gene therapy as a potent immunosuppressive treatment for liver transplantation in rats. Transplant. Proc. 33: 189, 2001. (Impact factor 1.0)
  69. Takehara, M., M. Murakami, I. Nakagawa, I. Saito, Y. Kanegae, M. Nomura, T. Ohmura, S. Todo and T. Uede. Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4Ig. Human Gene Therapy 12: 415-426, 2001. (Impact factor 4.0)
  70. Ueno, H., M. Murakami, M. Okumura, T. Kadosawa, T. Uede and T Fujinaga. Chitosan accelerates the production of osteopontin from polymorphonuclear leukocytes. Biomaterials 22: 1667-1673, 2001. (Impact factor 7.6)
  71. Ueno, H., F. Nakamura, M. Murakami, M. Okumura, T. Kadosawa and T. Fujinaga. Evaluation effects of chitosan for the extracellular matrix production by fibroblasts and the growth factors production by macrophages. Biomaterials 22:2130-2148, 2001. (Impact factor 7.6)
  72. Ijima, K., M. Murakami, H. Okamoto, M. Inobe, S. Chikuma, I. Saito, Y. Kanegae, Y. Kawaguchi, A. Kitabatake and T. Uede. Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4IgG in a murine model of type II collagen-induced arthritis. Human Gene Therapy 12: 1063-77, 2001. (Impact factor 4.0)
  73. Harada, H., H. Ishikura, I. Nakagawa, J. Shindou, M. Murakami, T. Uede, I. Koyanagi and T. Yoshiki. Donor-specific prolongation of survival of rat renal allografts by preoperative inoculation of CTLA4Ig plus allogeneic dendritic cells. Urol. Res. 28: 69-74, 2000. (Impact factor 1.6)
  74. Yamada, A., K. Konishi, G. L. Crus, M. Takehara, M. Morikawa, I. Nakagawa, M. Murakami, T. Abe, S. Todo and T. Uede. Blocking the CD28-B7 T-cell costimulatory pathway abrogates the development of obliterative bronchiolitis in a murine heterotopic airway model. Transplantation 69: 743-749, 2000. (Impact factor 3.8)
  75. Takiguchi, M., M. Murakami, I. Nakagawa, M. M. Rashid, N. Tosa, S. Chikuma, A. Hashimoto and T. Uede. Involvement CD28/CTLA4-B7 costimulatory pathway in the development of lymphadenopathy and splenomegary in MRL/lpr mice. J. Vet. Med. Sci. 62: 29-36, 2000. (Impact factor 0.9)
  76. Chiba, S., M. M. Rashid, H. Okamoto, H. Shiraiwa, S. Kon, M. Maeda, M. Murakami, M. Inobe, A. Kitabatake, A. F. Chambers and T. Uede. The role of osteopontin in the development of granulomatous lesions in lung. Microbiol. Immunol. 44, 319-332, 2000. (Impact factor 1.6)
  77. Chikuma, S., M. Murakami, K. Tanaka and T. Uede. Janus Kinase 2 is associated with box 1-like motif and phosphrylates a critical tyrosine residue in the cytoplasmic region of CTLA-4. J. Cell. Biochem. 78: 241-250, 2000. (Impact factor 3.1)
  78. *Ku, C. C., *M. Murakami, A. Sakamoto, J. Kappler and P. Marrack. Control of homeostasis of CD8+ memory T cells by opposing cytokines. (*equal contribution) Science 288: 675-678, 2000. (Impact factor 31.0)
  79. Katagiri, Y., T. Sleeman, H. Fujii, P. Herlich, H. Hotta, K. Tanaka, S. Chikuma, H. Yagita, K. Okumura, M. Murakami, I. Saiki, A. Chambers and T. Uede. CD44 variants but not CD44s cooperate with b1-containing integrins to permit cells to bind to osteopontin independently of RGD, there by stimulating cell motility and chemotaxis. Cancer Res. 59: 219-226, 1999. (Impact factor 8.7)
  80. Tarumi, K., M. Murakami, A. Yagihashi, I. Nakagawa, K. Hirata and T. Uede.  CTLA4IgG treatment induces long-term acceptance of rat small bowel allografts. Transplantation 67: 520-525, 1999. (Impact factor 3.8)
  81. Takiguchi, M., M. Murakami, I. Nakagawa, A. Yamada, S. Chikuma, A. Hashimoto and T. Uede. Blockade of CD28/CTLA4-B7 pathway prevented lymphadenopacy in MRL/lpr mice. Lab. Invest. 79: 317-326, 1999. (Impact factor 4.0)
  82. Asano, K., M. Murakami, D. Endo, T. Kimura and T. Fujinaga. Complementary DNA cloning, tissue distribution, and synthesis of canine brain natriuretic peptide. American J. Vet. Res. 7: 860-864, 1999. (Impact factor 1.4)
  83. Sato, J., K. Asakura, M. Murakami, T. Uede and A. Kataura. Suppressive effects of CTLA4-Ig on nasal allergic reactions in presensitized murine model. Life Sciences 64: 785-795, 1999. (Impact factor 2.6)
  84. Sato, J., K. Asakura, M. Murakami, T. Uede and A. Kataura. Topical CTLA4Ig suppresses ongoing mucosal immune response in presensitized murine model of allergic rhinitis. Int. Aarch. Allergy Immunol. 119: 197-200, 1999. (Impact factor 2.3)
  85. Takiguchi, M., M. Murakami, I. Nakagawa, A. Yamada, S. Chikuma, Y. Kawaguchi, A. Hashimoto and T. Uede. Blockade of CD28/CTLA4-B7 costimulatory pathway prevented autoantibody-related diseases but not lung diseases in MRL/lpr mice. Life Science 79: 317-326, 1999. (Impact factor 2.6)
  86. Yamashita, K., M. Nomura, T. Omura, M. Takehara, T. Suzuki, T. Shimamura, A. Kishida, H. Furukawa, M. Murakami, T. Uede and S. Todo. Effect of a novel immunosuppressant, FTY720, on heart and liver transplantations in rats. Transplant. Proc. 31: 1178-1179, 1999. (Impact factor 1.0)
  87. Fukumoto, T., N. Torigoe, S. Kawabata, M. Murakami, T. Uede, T. Nishi, Y. Ito and K. Sugimura. Peptide mimics of the CTLA4-binding domain stimulate T-cell proliferation. Nature Biothech. 16: 267-270, 1998. (Impact factor 32.4)
  88. Hakamida-Taguchi, R., T. Kato, H. Ushijima, M. Murakami, T. Uede and H. Nariuchi. Expression and co-stimulatory function of B7-2 on murine CD4+ T cells. Eur. J. Immunol. 28: 865-873, 1998. (Impact factor 5.0)
  89. Nakagawa, I., M. Murakami, K. Ijima, S. Chikuma, I. Saito, Y. Kanegae, H. Ishikura, T. Yoshiki, H. Okamoto, A. Kitabatake and T. Uede.  Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG. Human Gene Therapy 9: 1739-1745, 1998. (Corresponding Author, Impact factor 4.0)
  90. Iizuka, J., Y. Katagiri, N. Tada, M. Murakami, T. Ikeda, M. Sato, K. Hirokawa, S. Okada, M. Hatano, T. Tokuhisa and T. Uede.  Introduction of an osteopontin gene confers the increase in B1 cell population and the production of anti-DNA autoantibodies. Lab. Invest. 78: 1523-1533, 1998. (Impact factor 4.0)
  91. Tarumi, K., A. Yagihashi, M. Murakami, T. Uede and K. Hirata.  Prolongation of rat small bowel allograft survival by CTLA4Ig. Transplant. Proc. 30: 2596-2599, 1998. (Impact factor 1.0)
  92. Fujii, H., M. Inobe, Y. Hayakawa, F. Kimura, M. Murakami, Y. Ohnishi, I. Azuma, T. Uede and I. Saiki. Vaccination with B7-1+ tumor and antiadhesion therapy with RGD pseudo-peptide (FC-336) efficiently induce anti-metastatic effect. Clin. Exp. Metastasis 16: 141-148, 1998. (Impact factor 3.5)
  93. Isashi, Y., T. Yamashita, S. Nagasawa, K. Tanaka, M. Murakami and T. Uede. The mechanism by which proteolysis enhances the ligand-binding activity of guinea pig type II Fc receptor for IgG (FcgRII). J. Biochem. 123: 959-967, 1998. (Impact factor 2.7)
  94. Aoki, N., M. Inobe, M. Murakami, R. Abe and H. Iizuka. The functional role of B7 molecules on the induction of thymocyte activation and apoptosis. Microbiol. Immunol. 42: 5555-5565, 1998. (Impact factor 1.6)
  95. Hayakawa, M., S. Kawaguchi, S. Ishii, M. Murakami and T. Uede. B7-1-transfected tumor vaccine counteracts chemoterapy-induced immunosuppression and prolongs the survival of rats bearing highly metastatic osteosarcoma cells. Int. J. Cancer 72: 1-12, 1997. (Impact factor 6.2)
  96. Hara, T., M. Murakami, H. Maeda, M. Hibi and T. Uede. Involvement of common 10 amino acid segment in the cytoplasmic region of CD40 but different MAP kinases in different CD40-mediated respnses. Biochem. Biophys. Res. Commun. 233: 187-192, 1997. (Impact factor 2.4)
  97. Tsuchida, T., T. Naitoh, T. Takahashi, M. Usui, M. Murakami and T. Uede. Limb allografts in rats treated with anti-ICAM1 and anti-LFA1 monoclonal antibodies. J. Reconst. Microsurg. 13: 107-110, 1997. (Impact factor 1.0)
  98. Tsuchida, T., M. Usui, M. Murakami and T. Uede. Vascularized bone marrow allotransplantation in rats prolong the survival of simultaneously grafted alloskin, Transplant. Proc. 29: 1732-1733, 1997. (Impact factor 1.0)
  99. Kaneda, R., K. Iwabuchi, M. Kasai, M. Murakami, T. Uede and K. Onoe.  Selective antigen presenting activity of cortical thymic epithelial cells against CD4+ T cells associated with both lack of costimulatory molceules and in efficient presentation of MHC-peptide ligands. Cell. Immunol. 181: 163-171, 1997. (Impact factor 1.7)
  100. Fujii, H., M. Inobe, F. Kimura, J. Murata, M. Murakami, Y. Onishi, I. Azuma, T. Uede and I. Saiki.  Vaccination of tumor cells transfected with B7-1 (CD80) gene induces the anti-metastatic effect and tumor immunity in mice. Int. J. Cancer 66: 219-224, 1996. (Impact factor 6.2)
  101. Inobe, M., N. Aoki, P. S. Linsley, J. A. Ledbetter, M. Murakami and T. Uede. The role of B7-1a molecule, an alternatively spliced form of murine B7-1, on T cell activation. J. Immunol. 157: 582-588, 1996. (Impact factor 5.5)
  102. Katagiri, Y., M. Murakami, K. Mori, J. Iizuka, T. Hara, K. Tanaka, W.-Y. Jia, A. F. Chambers and T. Uede. Non-RGD domains of osteopontin promote cell adhesion without involving aV integrins. J. Cell Biochem. 62: 123-131, 1996. (Impact factor 3.1)
  103. Isashi, Y., T. Yamashita, S. Nagasawa, M. Murakami and T. Uede. Molecular cloning and characterization of gunia-pig FcgRIII: expression but not function is independent of the g chain of FceRI. Int. Immunol. 8: 1335-1346, 1996. (Impact factor 3.1)
  104. Yamada, A., M. Murakami, K. Ijima, H. Yagita, K. Okumura, S. Komatsu and T. Uede. Long-term acceptance of major histocompatibility complex-mismached cardiac allograft induced by a low dose of CTLA4IgM plus FK506. Microbiol. Immunol. 40: 513-518, 1996. (Impact factor 1.6)
  105. Murakami, M., Y. Takahashi, Y. Isashi, S. Kon, M. Inobe, R. Abe and T. Uede. Identification and characterization of an alternative CTLA4 binding molecule on B cells. Proc. Natl. Acad. Sci., U.S.A. 93: 7838-7842, 1996. (Impact factor 9.7)
  106. Katagiri, Y., K. Mori, T. Hara, K. Tanaka, M. Murakami and T. Uede.  Functional analysis of osteopontin molecule. Ann. N. Y. Acad. Sci. 760: 371-374, 1995. (Impact factor 4.4)
  107. Kamikubo, Y., M. Murakami, M. Imamura, T. Murashita, K. Yasuda and　T. Uede. Neutrophil-independent myocardial dysfunction during an early stage of global ischemia and repurfusion of isolated hearts. Immunopharmacology 29: 261-271, 1995. (Impact factor 2.4 as International Immunopharmacology)
  108. Yoneya, K., H. Okamoto, M. Machida, H. Onozuka, M. Noguchi, T. Mikami, H. Kawaguchi, M. Murakami, T. Uede and A. Kitabatake.  Angiotensin-converting enzyme gene polymorphism in japanese patients with hypertrophic cardiomypathy. American Heart J. 130: 1089-1093, 1995. (Impact factor 4.5)
  109. Isashi, Y., M. Tamakoshi, Y. Nagai, T. Sudo, M. Murakami and T. Uede.  The rat neutrophil low affinity Fc receptor for IgG: Moleculare cloning and functional characterization. Immunol. letters 46: 157-163, 1995. (Impact factor 2.3)
  110. Toyooka, K., S. Maruo, T. Iwahori, N. Yamamoto, X. G. Tai, R. Abe, Y. Takahama, M. Murakami, T. Uede, T. Hamaoka and H. Fujiwara. CD28 costimulatory signals induce IL-2 receptor expression on antigen stimulated virgin T cells by an IL-2-independent mechanisms. Int. Immunol. 8: 159-169, 1995. (Impact factor 3.1)
  111. Yawata, H., K. Yasukawa, S. Nastuka, M. Murakami, H. Yamasaki, M. Hibi, T. Taga and T. Kishimoto. Structure-function analysis of human IL-6 receptor: disscciation of amino acid residues required for IL-6 binding and for IL-6 siganl transduction through gp130. EMBO J. 12: 1705-1712, 1993. (Impact factor 9.8)
  112. Murakami, M., M. Hibi, T. Nakagawa, K. Yasukawa, K. Yamanishi, T. Taga and T. Kishimoto. IL-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 160: 1808-1810, 1993. (Impact factor 31.0)
  113. Liu, J., B. Modrell, A. Aruffo, J. S. Marken, T. Taga, K. Yasukawa, M. Murakami, T. Kishimoto and M. Shoyab. Interleukin-6 signal transducer gp130 mediates Oncostatin M signaling. J. Biol. Chem. 267: 16763-16766, 1992. (Impact factor 4.7)
  114. Falus, A., M. Hibi, M. Murakami, T. Taga and T. Kishimoto.  Regulation of IL-6 receptor and gp130 expression on human cell lines of lymphoid myeloid origin. Cytokine 4: 495-499, 1992. (Impact factor 2.5)
  115. Murakami, M., M. Narazaki, M. Hibi, H. Yawata, K. Yasukawa, M. Hamaguchi, T. Taga, and T. Kishimoto.  Critical cytoplasmic region of the IL-6 signal transducer, gp130, is conserved in the d receptor family. Proc. Natl. Acad. Sci. U.S.A. 88: 11349-11353, 1991. (Impact factor 9.7)
  116. Hibi, M., M. Murakami, M. Saito, T. Hirano, T. Taga and T. Kishimoto. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63: 1149-1157, 1990. (Impact factor 32.0)

Reviews

  1. Stofkova, A., and M. Murakami. Neural activity regulates autoimmune diseases through the gateway reflex. Bioelectric Med. 2019 In press.
  2. Murakami, M., D. Kamimura and T. Hirano. Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines. Immunity. 50(4), 812-831, 2019.
  3. Kamimura, D., and M. Murakami. Neural stimulations regulate the infiltration of immune cells into the CNS. J Intern Med. 2019 In press.
  4. Kamimura, D., T. Ohki, Y. Arima, M. Ota and M. Murakami. Gateway reflex: Local neuroimmune interactions that regulate blood vessels. Neurochem Int. 2018 In press.
  5. Kamimura, D., T. Ohki, Y. Arima, and M. Murakami. Gateway reflex: neural activation-mediated immune cell gateways in the central nervous system. Int Immunol. 30(7), 281-289, 2018 May 15. doi: 10.1093/intimm/dxy034.
  6. Tanaka, T., Y. Arima, D. Kamimura, and M. Murakami. The gateway reflex, a novel neuro-immune interaction for the regulation of regional vessels. Front Immunol Oct 18;8:1321, doi: 10.3389/fimmu.2017.01321. 2017
  7. Elfeky, M., D. Kamimura, Y. Arima, M. Murakami and L. Steinman. Targeting molecules involved in immune cell trafficking to the central nervous system for therapy in multiple sclerosis. Clin Exp Neuroimmun. 8(3), 183-191, 2017
  8. Murakami, M. Recent advances in neuroimmune interactions. Clin Exp Neuroimmunol. 8: 3-4, 2017
  9. Ohki, T., D. Kamimura, Y. Arima, M. Murakami. Gateway reflex, a new paradigm of neuro-immune interaction. Clin Exp Neuroimmun. 8, 23-32, 2017
  10. Nakagawa, I., D. Kamimura, T. Atsumi, Y. Arima, M. Murakami. Role of inflammation amplifier-induced growth factor expression in the development of inflammatory diseases. Crit Rev Immunol. 35(5), 365-78, 2015
  11. Kamimura, D., T. Atsumi, A. Stofkova, N. Nishikawa, T. Ohki, H. Suzuki, K. Katsunuma, J-J Jiang, H. Bando, J. Meng, L. Sabharwal, H. Ogura, T. Hirano, Y. Arima, M. Murakami. Naive T cell homeostasis regulated by stress responses and TCR signaling. Front Immunol 6, Article 638, 2015.
  12. Arima, Y., K. Higuchi, N. Nishikawa, A. Stofkova, T Ohki, D. Kamimura, M. Murakami. Pain is an inducer for relapse in multiple sclerosis models via a regional neural signal. Clin Exp Neuroimmunol. 6, 343-344, 2015
  13. Huseby, ES., D. Kamimura, Y. Arima, CS. Parello, K. Sasaki, M. Murakami. Role of T cell – glial cell interactions in creating and amplifying Central Nervous System inflammation and Multiple Sclerosis disease symptoms. Frontiers in Cellular Neuroscience. 9, Article 295, 2015. (Impact Factor 4.2) (Corresponding Author)
  14. Kamimura, D., A. Stofkova, N. Nishikawa, T. Atsumi, Y. Arima, M. Murakami.. Immune Cell Gateways in the CNS Regulated by Regional Neural Stimulations. Clin Exp Neuroimmunol. 6(2): 120–128, 2015 (Corresponding Author)
  15. Sabharwal, L.*, D. Kamimura* (*, equal contribution), J. Meng, H. Bando, H. Ogura, C. Nakayama, J-J. Jiang, N. Kumai, H. Suzuki, T. Atsumi, Y. Arima and M. Murakami.. The Gateway Reflex, which is mediated by the inflammation amplifier, directs pathogenic immune cells into the CNS. J Biochem 156(6):299-304, 2014 (Corresponding Author, Impact factor 3.1)
  16. Atsumi, T., R. Singh, L. Sabharwal, H. Bando, J. Meng, Y. Arima, M. Yamada, M. Harada, J.-J. Jiang, T. Hirano, D. Kamimura, H. Ogura, and M. Murakami. Inflammation amplifier, a new paradigm in cancer biology. Cancer Research 74: 8-14, 2014 (Corresponding Author, Impact factor 8.7)
  17. Ogura, H., D. Kamimura, Y. Arima and M. Murakami. The Inflammation Amplifier, an inducer of inflammation is critical for various human diseases and disorders. Arch. Immunol. Therapy. Experiment. 62: 41-45, 2014 (Corresponding Author, Impact factor 2.8)
  18. Singh, R., T. Atsumi, H. Bando, M. Harada, A. Nakamura, M. Yamada, J. Jiang, H. Suzuki, K. Katsunuma, T. Nodomi, D. Kamimura, H. Ogura, and M. Murakami. Reverse direction method: a possible tool to link animal models with corresponding human diseases and disorders. Int. J. Genomic Med. 1:106. doi: 10.4172/ijgm.1000106, 2013  (Corresponding Author, Impact factor N/A)
  19. Kamimura, D., H. Ogura, Y. Arima and M. Murakami. The Gateway Theory: Bridging Neural and Immune Signals in the CNS. Frontiers in Neuroendocrine Science doi: 10.3389/fnins.2013.00204 (Corresponding Author, Impact factor N/A)
  20. Arima, Y., D. Kamimura, H. Ogura and M. Murakami. Regulation of immune cell infiltration into the CNS by regional neural inputs explained by the gate theory. Mediators of Inflammationvol. 2013, Article ID 898165, 8 pages, 2013. doi:10.1155/2013/898165 (Corresponding Author, Impact factor 3.9)
  21. Ogura, H., Y. Arima, D. Kamimura and M. Murakami. Gate Theory; Regional Neural Activation Creates a Gateway for Immune Cells via Inflammation Amplifier. Biomedical Journal 36: 269-273, 2013 (Corresponding Author, Impact factor N/A)
  22. Murakmai, M. and T. Hirano. The Molecular Mechanisms of Chronic Inflammation Development, Front. Immunol., 15, http://dx.doi: 10.3389/fimmu.2012.00323, 2012. (Corresponding Author, Impact factor N/A)
  23. Murakami, M. and T. Hirano. The pathological and physiological roles of IL-6 amplifier activation. Int. J. Biol. Sci. 8: 1267-1280. 2012. (Corresponding Author, Impact factor 3.2)
  24. Fukada, T., K. Nishida, S. Yamazaki, M. Murakami and T. Hirano. Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem.16:1123-1134, 2011. (Impact factor 3.4)
  25. Murakami, M. and T. Hirano. A four step model for the IL-6 amplifier, a regulator of chromic inflammations in tissue specific MHC class II-associated autoimmune diseases. Front. Immunol. 22, http://dx.doi: 10.3389/fimmu.2011. 00022, 2011. (Impact factor N/A)
  26. Murakami, M. and T. Hirano. Intracellular Zinc homeostasis and Zinc signaling. Cancer Science 99:1515-22, 2008. (Impact factor 3.5)
  27. Hirano, T., M. Murakami, T. Fukada, K. Nishida, S. Yamasaki and T. Suzuki. Roles of Zinc and Zinc signaling in immunity: Zinc is an intracellular signaling molecule. Advances in Immunology. 97: 149-176, 2008. (Impact factor 7.3)
  28. Hirano, T. and M. Murakami. Grasp a pTyr-peptide by its SOCS. Dev. Cell 10:542-544, 2006. (Impact factor 12.9)
  29. Murakami, M., D. Kamimura and T. Hirano. New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27. Growth Factors 22:75-77, 2004. (Impact factor 2.2)
  30. Marrack, P., J. Bender, D. Hildeman, M. Jordan, T. Mitchell, M. Murakami, A. Sakamoto, B. C. Schaefer, B. Swanson and J. Kappler. Homeostasis of alpha and beta TCR+ T cells. Nature Immunol. 2: 107-111, 2000. (Impact factor 26.2)
  31. Uede, T., Y. Katagiri, J. Iizuka and M. Murakami. Osteopontin, a cordinator of host defense system: a cytokine or an extracellular adhesive protein? Microbiol. Immunol. 41: 641-648, 1997. (Impact factor 1.6)
  32. Kishimoto, T., M. Hibi, M. Murakami, M. Narazaki, M. Saito and T. Taga. The molecular biology of interleukin 6 and its receptor. Chiba-Found-Symp. 167: 5-23, 1992. (Impact factor 0.1)
  33. Taga, T., M. Hibi, M. Murakami, M. Saito, H. Yawata, M. Narazaki, Y. Hirata, T. Sugita, K. Yasukawa, T. Hirano and T. Kishimoto. Interleukin 6 receptor and signals. Chem. Immunol. 51:181-204, 1992. (Impact factor 3.6)
  34. Hirano, T., T. Taga, T. Matsuda, M. Hibi, S. Suematsu, B. Tang, M. Murakami and T. Kishimoto. Interleukin 6 and its receptor in the immune response and hematopoiesis. Int. J. Cell Cloning 8:155-167, 1990. (Impact factor 1.3)

Books

  1. Higuchi, K., D. Kamimura, A. Stofkova, N. Nishikawa, T. Ohki, Y. Arima, M. Murakami. Gateway reflexes are stimulated by neural activations and promote the pathogenesis of multiple sclerosis models. Nutrition and Lifestyle in Neurological Autoimmune Diseases. Chapter 5, 2016.
  2. Ota, M., D. Kamimura, I. Nakagawa, H. Higuchi, Y. Tanaka, M. Fujita, S. Hiratsuka, M. Okawara, K. Murakami, T. Atsumi, Y. Arima and M. Murakami. Control of chronic inflammation by the inflammation amplifier and gateway reflexes. Advances in Medicine and Biology Volume 104, 2016 In press
  3. Kamimura, D., Y. Arima, T. Atsumi, J. Meng, L. Sabharwal, H. Bando, J-J. Jiang, ES. Huseby, M. Murakami. Role of cytokine-mediated crosstalk between T cells and nonimmune cells in the pathophysiology of multiple sclerosis. Chapter 6 in Multiple Sclerosis (Elsevier) 2015 In press.
  4. Kamimura, D., Y. Arima, T. Hirano, H. Ogura, and M. Murakami. IL-6 and inflammatory diseases. Cytokine Frontiers: Regulation of Immune Responses in Health and Disease, edited by Tomohiro Yoshimoto and Takayuki Yoshimoto Tokyo Japan, 2013
  5. Nishida, K., T. Fukada, S. Yamasaki, M. Murakami and T. Hirano. Zinc in Allergy, Autoimmune, and Hard and Connective Tissue Diseases. in Zinc in Human Health edited by L. Rink., IOS Press, 2011
  6. Murakami, M., S. Sawa, D. Kamimura, H. Kamon, H. Kitamura, T. Kawabe, P. Sung-Joo, K. Ishihara and H. Toshio. Hyperactivation of gp130-mediated STAT3 signaling induces a rheumatoid arthritis-like disease that is dependent on MHC class II restricted CD4+ T cells. In The Innate Immune System: Strategies for Disease Control by M. Taniguchi, S. Akira, and T. Nakayama, Elsevier, USA. p.207-206, 2005.
  7. Taga, T., M. Hibi, M. Murakami, M. Saito, H. Yawata, M. Narazaki, Y. Hirata, T. Sugita, K. Yasukawa, T. Hirano and T. Kishimoto.  IL-6 receptor and signals. In Chemical Immunology: Interleukins: MolecularBiology and Immunology, ed. by Kishimoto, T., and S. Karger AG, Basel Switzerland. vol. 51, p181-204, 1992.
  8. Kishimoto, T., M. Hibi, M. Murakami, M. Narazaki, M. Saito and T. Taga. The molecular bioloby of interleukin 6 and its receptor. In Polyfunctional cytokines: IL-6 an LIF, edt. by Gregory R. Bock, Joan Marsh (Organizers) and Kate Widdows, John Wiley & Sons, Chichester. p.5-23, 1992.
  9. Taga, T., M. Hibi, M. Murakami, M. Saito, T. Hirano and T. Kishimoto. A new cytokine receptor family ans a novel signaling mechanism by receptor-associate IL-6 signal transducer, gp130. In Origins Human Cancer: A comprehensive Review. Cold Spring Harver Lab. Press, NY, USA. p277-284, 1991.
  10. Suematsu, S., M. Hibi, T. Sugita, M. Saito, M. Murakami, T. Matsusaka, T. Matsuda, T. Hirano, T. Taga and T. Kishimoto. Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma. In Current topics in microbiology and immunology Vol. 166, edt. by M. Potter and F. Melchers, Springer-Verlag Berlin Heidelberg. p.13-22, 1990.
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