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Research

  1. Neuro-immune interactions that regulate the pathogenesis of inflammatory diseases
  2. Inflammation amplifier; a molecular mechanism that promotes chronic inflammation

Major Achievements

Nat Commun. 6, Article number: 7474 (2015)
KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR
Cell Reports 3: 946-959 (2013)
Disease-Association Analysis of an Inflammation-Related Feedback Loop
Cell. 148: 447-457 (2012)
Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier
Immunity. Mar;30(3):447-57. (2009)
Hepatic IL-7 regulates T cell responses in vivo.
J. Exp. Med. 208: 103-114 (2011)
A 4 step model for MHC class II associated autoimmune diseases
Immunity, Vol 29, 628-636, 17 October 2008
Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction.
J. Clin. Invest. 117: 1270-1281, 2007
Omenn Syndrome ; a murine model is established.
Nature Immunol.7:971-977, 2006
(Published online: 6 August 2006; | doi:10.1038/ni1373).
Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.
J. Exp. Med. published on line 22 May 2006.
Autoimmune arthritis associated with mutated IL-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T.
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